ArticleProceedings of the National Academy of Sciences of the United States of America1999
Ubiquitination of RNA polymerase II large subunit signaled by phosphorylation of carboxyl-terminal domain.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 101 citations in OpenAlex.
- Natural degradation of RNA polymerase II is essential for oocyte chromatin reorganization and maternal-to-zygotic transition.Nature communications · 2025Article
- Transcriptional elongation control in developmental gene expression, aging, and disease.Molecular cell · 2023Review
- Article
- Causes and consequences of RNA polymerase II stalling during transcript elongation.Nature reviews. Molecular cell biology · 2021Review
- In vitro mechanistic studies on α-amanitin and its putative antidotes.Archives of toxicology · 2020Article
- The RNA polymerase III repressor MAF1 is regulated by ubiquitin-dependent proteasome degradation and modulates cancer drug resistance and apoptosis.The Journal of biological chemistry · 2019Article
- A SUMO-dependent pathway controls elongating RNA Polymerase II upon UV-induced damage.Scientific reports · 2019Article
- Review
- Human p53 interacts with the elongating RNAPII complex and is required for the release of actinomycin D induced transcription blockage.Scientific reports · 2017Article
- Intronic cleavage and polyadenylation regulates gene expression during DNA damage response through U1 snRNA.Cell discovery · 2016Article
- Degradation of DNA damage-independently stalled RNA polymerase II is independent of the E3 ligase Elc1.Nucleic acids research · 2014Article
- Promoters active in interphase are bookmarked during mitosis by ubiquitination.Nucleic acids research · 2012Article
- Triptolide (TPL) inhibits global transcription by inducing proteasome-dependent degradation of RNA polymerase II (Pol II).PloS one · 2011Article
- Circadian gene expression is resilient to large fluctuations in overall transcription rates.The EMBO journal · 2009Article
- Endothelial cell annexin A2 regulates polyubiquitination and degradation of its binding partner S100A10/p11.The Journal of biological chemistry · 2008Article
- Multiple mechanisms contribute to inhibit transcription in response to DNA damage.The Journal of biological chemistry · 2008Article
- The 3' processing factor CstF functions in the DNA repair response.Nucleic acids research · 2008Article
- The von Hippel-Lindau tumor suppressor protein and Egl-9-Type proline hydroxylases regulate the large subunit of RNA polymerase II in response to oxidative stress.Molecular and cellular biology · 2008Article
- Epidermal-growth-factor-dependent phosphorylation and ubiquitinylation of MAGE-11 regulates its interaction with the androgen receptor.Molecular and cellular biology · 2008Article
- Wwp2-mediated ubiquitination of the RNA polymerase II large subunit in mouse embryonic pluripotent stem cells.Molecular and cellular biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
A sensitive assay using biotinylated ubiquitin revealed extensive ubiquitination of the large subunit of RNA polymerase II during incubations of transcription reactions in vitro. Phosphorylation of the repetitive carboxyl-terminal domain of the large subunit was a signal for ubiquitination. Specific inhibitors of cyclin-dependent kinase (cdk)-type kinases suppress the ubiquitination reaction. These kinases are components of transcription factors and have been shown to phosphorylate the carboxyl-terminal domain. In both regulation of transcription and DNA repair, phosphorylation of the repetitive carboxyl-terminal domain by kinases might signal degradation of the polymerase.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.