ArticleInfection and immunity1999
Interleukin 5 (IL-5) is not required for expression of a Th2 response or host resistance mechanisms during murine schistosomiasis mansoni but does play a role in development of IL-4-producing non-T, non-B cells.
Article in Infection and immunity, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 48 citations in OpenAlex.
- A major ecological niche of eosinophils in evolvingScience advances · 2025Article
- Contribution of parasite and host genotype to immunopathology of schistosome infections.Parasites & vectors · 2024Article
- Contribution of parasite and host genotype to immunopathology of schistosome infections.bioRxiv : the preprint server for biology · 2024Article
- Chronic schistosome infection leads to modulation of granuloma formation and systemic immune suppression.Frontiers in immunology · 2013Article
- Do helminths cause epilepsy?Parasite immunology · 2009Review
- Protective immune mechanisms in helminth infection.Nature reviews. Immunology · 2007Review
- Article
- Interleukin-5 (IL-5) augments the progression of liver fibrosis by regulating IL-13 activity.Infection and immunity · 2006Article
- In vivo imaging of tissue eosinophilia and eosinopoietic responses to schistosome worms and eggs.International journal for parasitology · 2005Article
- Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice.The Journal of experimental medicine · 2001Article
- Cysteine protease secreted by Paragonimus westermani attenuates effector functions of human eosinophils stimulated with immunoglobulin G.Infection and immunity · 2001Article
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
During schistosomiasis, interleukin-5 (IL-5)-dependent eosinophil responses have been implicated in immunopathology, resistance to superinfection, synergistic interactions with chemotherapeutic agents, and the inductive phase of the egg-induced Th2 response. We examined these issues in IL-5-deficient (IL-5(-/-)) mice. IL-5(-/-) and wild-type (WT) mice were indistinguishable in terms of susceptibility to primary infections and the ability to resist secondary infections. Moreover, hepatic pathology was similar in both strains apart from a relative lack of eosinophils and, during chronic infection, a significantly larger mast cell component in the granulomas of IL-5(-/-) mice. Splenocyte cytokine production in response to soluble egg antigen (SEA) or anti-CD3 revealed no significant differences except for heightened tumor necrosis factor alpha production by cells from chronically infected IL-5(-/-) mice compared to WT animals. In contrast, ionomycin-stimulated non-B, non-T (NBNT) cells from IL-5(-/-) mice produced significantly smaller IL-4 amounts than did NBNT cells from WT animals. This difference was not apparent following plate-bound anti-immunoglobulin E or SEA stimulation. The absence of IL-5 failed to affect the induction of Th2 responses in naive mice. Peritoneal exudate cells recovered from egg-injected IL-5(-/-) or WT mice produced equivalent levels of IL-4 following restimulation with SEA or anti-CD3.
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