ArticleJournal of anatomy1999
Histochemical and immunohistochemical analysis of the mechanism of calcification of Meckel's cartilage during mandible development in rodents.
Article in Journal of anatomy, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 56 citations in OpenAlex.
- Identification of IDUA and WNT16 Phosphorylation-Related Non-Synonymous Polymorphisms for Bone Mineral Density in Meta-Analyses of Genome-Wide Association Studies.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Pooled it
- The relationship between Meckel's cartilage resorption and incisor tooth germ in mice.Journal of anatomy · 2023Article
- Spatial and chronological localization of septoclasts in the mouse Meckel's cartilage.Histochemistry and cell biology · 2022Article
- Meckel's Cartilage in Mandibular Development and Dysmorphogenesis.Frontiers in genetics · 2022Article
- The Mandibular and Hyoid Arches-From Molecular Patterning to Shaping Bone and Cartilage.International journal of molecular sciences · 2021Review
- Diverse Fate of an Enigmatic Structure: 200 Years of Meckel's Cartilage.Frontiers in cell and developmental biology · 2020Review
- MicroRNA-214 promotes the calcification of human aortic valve interstitial cells through the acceleration of inflammatory reactions with activated MyD88/NF-κB signaling.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Meckel's and condylar cartilages anomalies in achondroplasia result in defective development and growth of the mandible.Human molecular genetics · 2016Article
- Diabetic Mesenchymal Stem Cells Are Ineffective for Improving Limb Ischemia Due to Their Impaired Angiogenic Capability.Cell transplantation · 2015Article
- The complex ontogenetic trajectory of mandibular shape in a laboratory mouse.Journal of anatomy · 2013Article
- Two sides of MGP null arterial disease: chondrogenic lesions dependent on transglutaminase 2 and elastin fragmentation associated with induction of adipsin.The Journal of biological chemistry · 2013Article
- Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease.Journal of molecular and cellular cardiology · 2013Article
- Involvement of fibroblast growth factor receptor genes in benign prostate hyperplasia in a Korean population.Disease markers · 2013Article
- An immunohistochemistry study of Sox9, Runx2, and Osterix expression in the mandibular cartilages of newborn mouse.BioMed research international · 2013Article
- Attenuation of chondrogenic transformation in vascular smooth muscle by dietary quercetin in the MGP-deficient mouse model.PloS one · 2013Article
- Effects of miR-335-5p in modulating osteogenic differentiation by specifically downregulating Wnt antagonist DKK1.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Inhibitory role of Notch1 in calcific aortic valve disease.PloS one · 2011Article
- Cytomegalovirus induces abnormal chondrogenesis and osteogenesis during embryonic mandibular development.BMC developmental biology · 2008Article
- Hand transcription factors cooperatively regulate development of the distal midline mesenchyme.Developmental biology · 2007Article
- Immunolocalization of receptor activator of nuclear factor-kappaB ligand (RANKL) and osteoprotegerin (OPG) in Meckel's cartilage compared with developing endochondral bones in mice.Journal of anatomy · 2005Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is widely accepted that Meckel's cartilage in mammals is uncalcified hyaline cartilage that is resorbed and is not involved in bone formation of the mandible. We examined the spatial and temporal characteristics of matrix calcification in Meckel's cartilage, using histochemical and immunocytochemical methods, electron microscopy and an electron probe microanalyser. The intramandibular portion of Meckel's cartilage could be divided schematically into anterior and posterior portions with respect to the site of initiation of ossification beneath the mental foramen. Calcification of the matrix occurred in areas in which alkaline phosphatase activity could be detected by light and electron microscopy and by immunohistochemical staining. The expression of type X collagen was restricted to the hypertrophic cells of intramandibular Meckel's cartilage, and staining with alizarin red and von Kossa stain revealed that calcification progressed in both posterior and anterior directions from the primary centre of ossification. After the active cellular resorption of calcified cartilage matrix, new osseous islands were formed by trabecular bone that intruded from the perichondrial bone collar. Evidence of such formation of bone was supported by results of double immunofluorescence staining specific for type I and type II collagens, in addition to results of immunostaining for osteopontin. Calcification of the posterior portion resembled that in the anterior portion of intramandibular Meckel's cartilage, and our findings indicate that the posterior portion also contributes to the bone formation of the mandible by an endochondral-type mechanism of calcification.
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