ArticleRNA (New York, N.Y.)1999
Combinatorial control of a neuron-specific exon.
Article in RNA (New York, N.Y.), 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed.
- The Rbfox1/LASR complex controls alternative pre-mRNA splicing by recognition of multipart RNA regulatory modules.Genes & development · 2025Article
- The RNA-binding proteins hnRNP H and F regulate splicing of a MYC-dependent HRAS exon in prostate cancer cells.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Dose-dependent action of the RNA binding protein FOX-1 to relay X-chromosome number and determineeLife · 2020Article
- Identification and Characterization of a Minimal Functional Splicing Regulatory Protein, PTBP1.Biochemistry · 2020Article
- Multiple determinants of splicing repression activity in the polypyrimidine tract binding proteins, PTBP1 and PTBP2.RNA (New York, N.Y.) · 2016Article
- Alternative Splicing Shapes the Phenotype of a Mutation in BBS8 To Cause Nonsyndromic Retinitis Pigmentosa.Molecular and cellular biology · 2015Article
- Context-dependent control of alternative splicing by RNA-binding proteins.Nature reviews. Genetics · 2014Review
- Effects of RNAi-mediated knockdown of histone methyltransferases on the sex-specific mRNA expression of Imp in the silkworm Bombyx mori.International journal of molecular sciences · 2014Article
- Alternative pre-mRNA splicing in neurons: growing up and extending its reach.Trends in genetics : TIG · 2013Review
- Regulation of the mutually exclusive exons 8a and 8 in the CaV1.2 calcium channel transcript by polypyrimidine tract-binding protein.The Journal of biological chemistry · 2011Article
- SR proteins induce alternative exon skipping through their activities on the flanking constitutive exons.Molecular and cellular biology · 2011Article
- Identification of a male-specific RNA binding protein that regulates sex-specific splicing of Bmdsx by increasing RNA binding activity of BmPSI.Molecular and cellular biology · 2010Article
- Intronic motif pairs cooperate across exons to promote pre-mRNA splicing.Genome biology · 2010Article
- Splice site strength-dependent activity and genetic buffering by poly-G runs.Nature structural & molecular biology · 2009Article
- Developmental control of CaV1.2 L-type calcium channel splicing by Fox proteins.Molecular and cellular biology · 2009Article
- Control of alternative pre-mRNA splicing by Ca(++) signals.Biochimica et biophysica acta · 2008Review
- A G-tract element in apoptotic agents-induced alternative splicing.Nucleic acids research · 2008Article
- Multifactorial interplay controls the splicing profile of Alu-derived exons.Molecular and cellular biology · 2008Article
- Splicing regulation: from a parts list of regulatory elements to an integrated splicing code.RNA (New York, N.Y.) · 2008Review
- Imaging the alternative silencing of FGFR2 exon IIIb in vivo.RNA (New York, N.Y.) · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The mouse c-src gene contains a short neuron-specific exon, N1. N1 exon splicing is partly controlled by an intronic splicing enhancer sequence that activates splicing of a heterologous reporter exon in both neural and nonneural cells. Here we attempt to dissect all of the regulatory elements controlling the N1 exon and examine how these multiple elements work in combination. We show that the 3' splice site sequence upstream of exon N1 represses the activation of splicing by the downstream intronic enhancer. This repression is stronger in nonneural cells and these two regulatory sequences combine to make a reporter exon highly cell-type specific. Substitution of the 3' splice site of this test exon with sites from other exons indicates that activation by the enhancer is very dependent on the nature of the upstream 3' splice site. In addition, we identify a previously uncharacterized purine-rich sequence within exon N1 that cooperates with the downstream intronic enhancer to increase exon inclusion. Finally, different regulatory elements were tested in multiple cell lines of both neuronal and nonneuronal origin. The individual splicing regulatory sequences from the src gene vary widely in their activity between different cell lines. These results demonstrate how a simple cassette exon is controlled by a variety of regulatory elements that only in combination will produce the correct tissue specificity of splicing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.