ArticleDiabetes care1999
Fasting blood glucose: an underestimated risk factor for cardiovascular death. Results from a 22-year follow-up of healthy nondiabetic men.
Article in Diabetes care, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Markers of dysglycaemia and risk of coronary heart disease in people without diabetes: Reykjavik prospective study and systematic review.PLoS medicine · 2010Pooled it
- Pioglitazone ameliorates endothelial dysfunction in those with impaired glucose regulation among the first-degree relatives of type 2 diabetes mellitus patients.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2013Trial
- Association of biochemical indicators with multimorbidity in 19,624 older adult individuals with chronic diseases: a study from Jindong District, Jinhua City, China.Frontiers in public health · 2025Article
- Molecular insights of exercise therapy in disease prevention and treatment.Signal transduction and targeted therapy · 2024Review
- Fasting plasma glucose levels are associated with all-cause and cancer mortality: A population-based retrospective cohort study.PloS one · 2024Article
- The associations between health-related physical fitness and fasting blood glucose in war veterans: a population-based study.Scientific reports · 2022Article
- Circulating metabolite homeostasis achieved through mass action.Nature metabolism · 2022Article
- Fasting glucose level and all-cause or cause-specific mortality in Korean adults: a nationwide cohort study.The Korean journal of internal medicine · 2021Article
- Article
- Grading effect of abnormal glucose status on arterial stiffness and a new threshold of 2-h post-load glucose based on a Chinese community study.Journal of diabetes investigation · 2017Article
- Susceptibility to type 2 diabetes may be modulated by haplotypes in G6PC2, a target of positive selection.BMC evolutionary biology · 2017Article
- Effect of Fasting Blood Glucose Level on Heart Rate Variability of Healthy Young Adults.PloS one · 2016Article
- Association of Insulin Resistance, Arterial Stiffness and Telomere Length in Adults Free of Cardiovascular Diseases.PloS one · 2015Article
- Continuous noninvasive monitoring of changes in human skin optical properties during oral intake of different sugars with optical coherence tomography.Biomedical optics express · 2014Article
- Assessment of the Association between Mean Hemoglobin A1c Levels for 5 Years and Coronary Artery Disease by Coronary Angiography in Nondiabetic Patients.Diabetes & metabolism journal · 2014Article
- Article
- Diabetes mellitus and risk of hepatocellular carcinoma: findings from the Singapore Chinese Health Study.British journal of cancer · 2013Article
- Exercise training improves fasting glucose control.Open access journal of sports medicine · 2012Article
- Detection of glucose abnormalities in patients with acute coronary heart disease: study of reliable tools in clinical practice.Journal of endocrinological investigation · 2012Article
- Increased arterial stiffness in healthy subjects with high-normal glucose levels and in subjects with pre-diabetes.Cardiovascular diabetology · 2011Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveBecause of the available conflicting epidemiological data, we investigated the possible impact of fasting blood glucose as a risk factor for cardiovascular death in nondiabetic men. This study reports the results from a 22-year prospective study on fasting blood glucose as a predictor of cardiovascular death. RESEARCH DESIGN AND
methodsOf the 1,998 apparently healthy nondiabetic men (aged 40-59 years), a total of 1,973 with fasting blood glucose < 110 mg/dl were included in the study in which also a number of conventional risk factors were measured at baseline.
resultsAfter 22 years of follow-up, 483 men had died, 53% from cardiovascular diseases. After dividing men into quartiles of fasting blood glucose level, it was found that men in the highest glucose quartile (fasting blood glucose > 85 mg/dl) had a significantly higher mortality rate from cardiovascular diseases compared with those in the three lowest quartiles. Even after adjusting for age, smoking habits, serum lipids, blood pressure, forced expiratory volume in 1 s, and physical fitness (Cox model), the relative risk of cardiovascular death for men with fasting blood glucose > 85 mg/dl remained 1.4 (95% CI 1.04-1.8). Noncardiovascular deaths were unrelated to fasting blood glucose level.
conclusionsFasting blood glucose values in the upper normal range appears to be an important independent predictor of cardiovascular death in nondiabetic apparently healthy middle-aged men.
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