ArticleDiabetes care1999
Is there a glycemic threshold for mortality risk?
Article in Diabetes care, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Efficacy and safety outcomes of dulaglutide by baseline HbA1c: A post hoc analysis of the REWIND trial.Diabetes, obesity & metabolism · 2022Article
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- Prediabetes and Cardiovascular Disease: Pathophysiology and Interventions for Prevention and Risk Reduction.Endocrinology and metabolism clinics of North America · 2018Review
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- Inverse association between fasting plasma glucose and risk of ventricular arrhythmias.Diabetologia · 2015Article
- Glucokinase MODY and implications for treatment goals of common forms of diabetes.Current diabetes reports · 2014Review
- Fasting glucose level and the risk of incident atherosclerotic cardiovascular diseases.Diabetes care · 2013Article
- Low hemoglobin A(1c) in nondiabetic adults: an elevated risk state?Diabetes care · 2012Article
- Fasting glucose levels within the high normal range predict cardiovascular outcome.American heart journal · 2012Article
- Assessment of coronary heart diseases in diabetics in al-Madinah al-Munawarah.International journal of general medicine · 2012Article
- Type 2 diabetes and cardiovascular diseases: do they share a common soil? The Asian Indian experience.Heart Asia · 2012Article
- Postprandial glucose: marker or risk factor?Diabetes care · 2011Article
- Categories of glucose tolerance and continuous glycemic measures and mortality.European journal of epidemiology · 2011Article
- Article
- Article
- Article
- Diabetes increases large artery diseases, but not small artery diseases in the brain.Journal of neurology · 2008Article
- Glucose and insulin measurements from the oral glucose tolerance test and mortality prediction.Diabetes care · 2008Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether there are thresholds for fasting and for 2-h glucose above which the risk of death from all causes and from coronary heart disease (CHD) increases. RESEARCH DESIGN AND
methodsWe studied 23-year mortality data from the Paris Prospective Study of the 7,018 men, aged 44-55 years, who were not known as diabetic at the baseline examination. The effect of glucose concentrations on mortality was studied using the observed relative risks and an age-adjusted Cox proportional hazards model.
resultsFor all causes of death, there were J-shaped relationships with both fasting and 2-h glucose concentrations, and the lowest observed death rates were in the intervals centered on 5.5 mmol/l for fasting glucose and 5.0 mmol/l for 2-h glucose. The death rates for CHD were low in this population: for fasting glucose, the hazards ratio was best modeled by a positive linear relationship; for 2-h glucose, it was modeled by a J-shaped curve and the lowest observed death rate was in the interval centered on 6.0 mmol/l.
conclusionsIn the Paris Prospective Study, there were no clear thresholds for fasting or 2-h glucose concentrations above which mortality sharply increased; in the upper levels of the glucose distributions, the risk of death progressively increased with increasing fasting and 2-h glucose concentrations.
Indexed as
Identifiers
10332668What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.