ArticleThe Journal of physiology1999
Electrophysiological and morphological heterogeneity of rat dorsal vagal neurones which project to specific areas of the gastrointestinal tract.
Article in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed.
- Experience-dependent development of vagal circuitry in rodents and humans.Neuroscience and biobehavioral reviews · 2026Review
- Central control of gastrointestinal functions in health and disease.Physiological reviews · 2026Review
- Direct vagal input to the gastrointestinal tract and other viscera: Re-definition of autonomic neuroscience or experimental artifacts?Autonomic neuroscience : basic & clinical · 2025Review
- Article
- Article
- The substantia nigra modulates proximal colon tone and motility in a vagally-dependent manner in the rat.The Journal of physiology · 2023Article
- Stress-induced neuroplasticity in the gastric response to brainstem oxytocin in male rats.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- DMV extrasynaptic NMDA receptors regulate caloric intake in rats.JCI insight · 2021Article
- FGF19 in the Hindbrain Lowers Blood Glucose and Alters Excitability of Vagal Motor Neurons in Hyperglycemic Mice.Endocrinology · 2021Article
- Central Neurocircuits Regulating Food Intake in Response to Gut Inputs-Preclinical Evidence.Nutrients · 2021Review
- Fibroblast Growth Factor 19 Increases the Excitability of Pre-Motor Glutamatergic Dorsal Vagal Complex Neurons From Hyperglycemic Mice.Frontiers in endocrinology · 2021Article
- Protein Kinase C-Dependent Effects of Neurosteroids on Synaptic GABAFrontiers in physiology · 2021Article
- Interplay Between Systemic Metabolic Cues and Autonomic Output: Connecting Cardiometabolic Function and Parasympathetic Circuits.Frontiers in physiology · 2021Review
- Parkinson disease and the gut: new insights into pathogenesis and clinical relevance.Nature reviews. Gastroenterology & hepatology · 2020Review
- GABAJournal of neurophysiology · 2019Article
- Characterization of the Basic Membrane Properties of Neurons of the Rat Dorsal Motor Nucleus of the Vagus in Paraquat-Induced Models of Parkinsonism.Neuroscience · 2019Article
- Perinatal high-fat diet alters development of GABAAmerican journal of physiology. Gastrointestinal and liver physiology · 2019Article
- Neurophysiology of the brain stem in Parkinson's disease.Journal of neurophysiology · 2019Review
- A hindbrain inhibitory microcircuit mediates vagally-coordinated glucose regulation.Scientific reports · 2019Article
- Central control of gastrointestinal motility.Current opinion in endocrinology, diabetes, and obesity · 2019Review
17 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
1. The electrophysiological properties of rat dorsal motor nucleus of the vagus (DMV) neurones (n = 162) were examined using whole cell patch clamp recordings from brainstem slices. Recordings were made from DMV neurones whose projections to the gastrointestinal tract had been identified by previously applying fluorescent retrograde tracers to the gastric fundus, corpus or antrum/pylorus, or to the duodenum or caecum. 2. The neuronal groups were markedly heterogeneous with respect to several electrophysiological properties. For example, neurones which projected to the fundus had a higher input resistance (400 +/- 25 Momega), a smaller and shorter after-hyperpolarization (16.7 +/- 0.49 mV and 63.5 +/- 3.9 ms) and a higher frequency of action potential firing (19.3 +/- 1.4 action potentials s-1) following injection of depolarizing current (270 pA) when compared with caecum-projecting neurones (302 +/- 22 Momega; 23. 5 +/- 0.87 mV and 81.1 +/- 5.3 ms; 9.7 +/- 1.1 action potentials s-1; P < 0.05 for each parameter). Differences between neuronal groups were also apparent with respect to the distribution of several voltage-dependent potassium currents. Inward rectification was present only in caecum-projecting neurones, for example. 3. Neurones (n = 82) were filled with the intracellular stain Neurobiotin allowing post-fixation morphological reconstruction. Neurones projecting to the caecum had the largest cell volume (5238 +/- 535 microm3), soma area (489 +/- 46 microm2) and soma diameter (24.6 +/- 1.24 microm) as well as the largest number of dendritic branch segments (23 +/- 2). 4. In summary, these results suggest that DMV neurones are heterogeneous with respect to some electrophysiological as well as some morphological properties and can be divided into subgroups according to their gastrointestinal projections.
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