ReviewThe Journal of physiology1999
Aquaporin water channels in gastrointestinal physiology.
Review in The Journal of physiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
91 citing papers in PubMed, 293 citations in OpenAlex.
- Measurement of drug concentration in the stomach after intragastric administration of drug solution to healthy volunteers: analysis of intragastric fluid dynamics and drug absorption.Pharmaceutical research · 2013Trial
- Intravenous fluid restriction after major abdominal surgery: a randomized blinded clinical trial.Trials · 2009Trial
- Article
- Anti-Cryptosporidium efficacy of BKI-1708, an inhibitor of Cryptosporidium calcium-dependent protein kinase 1.PLoS neglected tropical diseases · 2025Article
- Intestinal gene expression in heat-stressed broilers selected for high water efficiency.Frontiers in physiology · 2025Article
- MOMASTAntioxidants (Basel, Switzerland) · 2024Article
- Golden Flower Tibetan Tea Polysaccharides Alleviate Constipation in Mice by Regulating Aquaporins-Mediated Water Transport System and Gut Microbiota.Foods (Basel, Switzerland) · 2024Article
- The multi-tissue gene expression and physiological responses of water deprived Peromyscus eremicus.BMC genomics · 2024Article
- When the tap runs dry: The multi-tissue gene expression and physiological responses of water deprivedbioRxiv : the preprint server for biology · 2024Article
- The Potential Application of Aloe Barbadensis Mill. as Chinese Medicine for Constipation: Mini-Review.Drug design, development and therapy · 2024Review
- Review
- Influence of SGLT1 Sugar Uptake Inhibitors on Water Transport.Molecules (Basel, Switzerland) · 2023Article
- Roles and regulation of Aquaporin-3 in maintaining the gut health: an updated review.Frontiers in physiology · 2023Review
- Aquaporins in Glandular Secretion.Advances in experimental medicine and biology · 2023Article
- Aquaporins in Digestive System.Advances in experimental medicine and biology · 2023Article
- Niacin Improves Intestinal Health through Up-Regulation of AQPs Expression Induced by GPR109A.International journal of molecular sciences · 2022Article
- Helicobacter pylori infection activates Wnt/β-catenin pathway to promote the occurrence of gastritis by upregulating ASCL1 and AQP5.Cell death discovery · 2022Article
- The glymphatic hypothesis: the theory and the evidence.Fluids and barriers of the CNS · 2022Review
- Aquaporin 8ab is required in zebrafish embryonic intestine development.Acta biochimica et biophysica Sinica · 2022Article
- Dysnatremia in Gastrointestinal Disorders.Frontiers in medicine · 2022Review
31 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Fluid transport is a major function of the gastrointestinal (GI) tract with more than 9 litres of fluid being absorbed or secreted across epithelia in human salivary gland, stomach, the hepatobiliary tract, pancreas, small intestine and colon. This review evaluates the evidence that aquaporin-type water channels are involved in GI fluid transport. The aquaporins are a family of small ( approximately 30 kDa) integral membrane proteins that function as water channels. At least seven aquaporins are expressed in various tissues in the GI tract: AQP1 in intrahepatic cholangiocytes, AQP4 in gastric parietal cells, AQP3 and AQP4 in colonic surface epithelium, AQP5 in salivary gland, AQP7 in small intestine, AQP8 in liver, pancreas and colon, and AQP9 in liver. There are functional data suggesting that some GI cell types expressing aquaporins have high or regulated water permeability; however, there has been no direct evidence for a role of aquaporins in GI physiology. Recently, transgenic mice have been generated with selective deletions of various aquaporins. Preliminary evaluation of GI function suggests a role for AQP1 in dietary fat processing and AQP4 in colonic fluid absorption. Further study of aquaporin function in the GI tract should provide new insights into normal GI physiology and disease mechanisms, and may yield novel therapies to regulate fluid movement in GI diseases.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.