ArticleArchives of disease in childhood1999
Treatment of nephrogenic diabetes insipidus with hydrochlorothiazide and amiloride.
Article in Archives of disease in childhood, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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Who cites it
19 citing papers in PubMed, 86 citations in OpenAlex.
- Identification of a novel large deletion mutation in theTranslational pediatrics · 2026Article
- Beyond expensive innovations: affordable and effective strategies for managing tubulopathies in adults.Clinical kidney journal · 2026Review
- International expert consensus statement on the diagnosis and management of congenital nephrogenic diabetes insipidus (arginine vasopressin resistance).Nature reviews. Nephrology · 2025Review
- Novel AVPR2 mutations in congenital nephrogenic diabetes insipidus: clinical characteristics and genetic analysis.Frontiers in pediatrics · 2025Article
- Atorvastatin does not ameliorate nephrogenic diabetes insipidus induced by lithium or potassium depletion in mice.Physiological reports · 2021Article
- Use of diuretics in the neonatal period.Pediatric nephrology (Berlin, Germany) · 2021Review
- EGF Receptor Inhibition by Erlotinib Increases Aquaporin 2-Mediated Renal Water Reabsorption.Journal of the American Society of Nephrology : JASN · 2016Article
- Identification of Potential Pharmacoperones Capable of Rescuing the Functionality of Misfolded Vasopressin 2 Receptor Involved in Nephrogenic Diabetes Insipidus.Journal of biomolecular screening · 2016Article
- A novel therapeutic effect of statins on nephrogenic diabetes insipidus.Journal of cellular and molecular medicine · 2015Review
- Pre- and post-treatment urinary tract findings in children with nephrogenic diabetes insipidus.Pediatric nephrology (Berlin, Germany) · 2014Article
- Nephrogenic diabetes insipidus: essential insights into the molecular background and potential therapies for treatment.Endocrine reviews · 2013Review
- Congenital nephrogenic diabetes insipidus: the current state of affairs.Pediatric nephrology (Berlin, Germany) · 2012Review
- Pediatric disorders of water balance.Pediatric clinics of North America · 2011Article
- Pediatric disorders of water balance.Endocrinology and metabolism clinics of North America · 2009Review
- Diuretics in pediatrics : current knowledge and future prospects.Paediatric drugs · 2006Review
- Efficacy of COX-2 inhibitors in a case of congenital nephrogenic diabetes insipidus.Pediatric nephrology (Berlin, Germany) · 2005Article
- Nephrogenic diabetes insipidus presenting with developmental delay and intracranial calcification.Indian journal of pediatrics · 2005Article
- Diabetes insipidus in children: pathophysiology, diagnosis and management.Paediatric drugs · 2002Review
- Management of hyponatraemia in patients with acute cerebral insults.Archives of disease in childhood · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nephrogenic diabetes insipidus (NDI) is characterised by the inability of the kidney to concentrate urine in response to arginine vasopressin. The consequences are severe polyuria and polydipsia, often associated with hypertonic dehydration. Intracerebral calcification, seizures, psychosomatic retardation, hydronephrosis, and hydroureters are its sequelae. In this study, four children with NDI were treated with 3 mg/kg/day hydrochlorothiazide and 0.3 mg/kg/day amiloride orally three times a day for up to five years. While undergoing treatment, none of the patients had signs of dehydration or electrolyte imbalance, all showed normal body growth, and there was no evidence of cerebral calcification or seizures. All but one had normal psychomotor development and normal sonography of the urinary tract. However, normal fluid balance was not attainable (fluid intake, 3.8-7.7 l/m2/day; urine output, 2.2-7.4 l/m2/day). The treatment was well tolerated and no side effects could be detected. Prolonged treatment with hydrochlorothiazide/amiloride appears to be more effective and better tolerated than just hydrochlorothiazide. Its efficacy appears to be similar to that of hydrochlorothiazide/indomethacin but without their severe side effects.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.