ArticleProceedings. Biological sciences1999
Selection for high and low virulence in the malaria parasite Plasmodium chabaudi.
Article in Proceedings. Biological sciences, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Scientists' Warning on the Rapid Evolution of Parasites in the Anthropocene.Evolutionary applications · 2026Article
- Virulence is associated with daily rhythms in the within-host replication of the malaria parasiteEvolutionary applications · 2024Article
- Controlled human malaria infections by mosquito bites induce more severe clinical symptoms than asexual blood-stage challenge infections.EBioMedicine · 2022Article
- Untapped potential: The utility of drylands for testing eco-evolutionary relationships between hosts and parasites.International journal for parasitology. Parasites and wildlife · 2020Article
- Contrasting evolution of virulence and replication rate in an emerging bacterial pathogen.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Genetically diverse Plasmodium falciparum infections, within-host competition and symptomatic malaria in humans.Scientific reports · 2019Article
- Adaptive phenotypic plasticity in malaria parasites is not constrained by previous responses to environmental change.Evolution, medicine, and public health · 2019Article
- The impact of within-host ecology on the fitness of a drug-resistant parasite.Evolution, medicine, and public health · 2018Article
- Genomic and transcriptomic comparisons of closely related malaria parasites differing in virulence and sequestration pattern.Wellcome open research · 2018Article
- Avian malaria: a new lease of life for an old experimental model to study the evolutionary ecology of Plasmodium.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Article
- Mosquitoes Reset Malaria Parasites.PLoS pathogens · 2015Article
- Blood-stage immunity to Plasmodium chabaudi malaria following chemoprophylaxis and sporozoite immunization.eLife · 2015Article
- Malaria-induced changes in host odors enhance mosquito attraction.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- The role of immunity in mosquito-induced attenuation of malaria virulence.Malaria journal · 2014Article
- Disrupting rhythms in Plasmodium chabaudi: costs accrue quickly and independently of how infections are initiated.Malaria journal · 2013Article
- Article
- Virulence evolution in a host-parasite system in the absence of viral evolution.Evolutionary ecology research · 2013Article
- Virulence, drug sensitivity and transmission success in the rodent malaria, Plasmodium chabaudi.Proceedings. Biological sciences · 2012Article
- The evolutionary consequences of blood-stage vaccination on the rodent malaria Plasmodium chabaudi.PLoS biology · 2012Article
- The evolution of host protection by vertically transmitted parasites.Proceedings. Biological sciences · 2011Article
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Funding
No grant is acknowledged in the PubMed record.
Abstract
What stops parasites becoming ever more virulent? Conventional wisdom and most parasite-centred models of the evolution of virulence suppose that risk of host (and, hence, parasite) death imposes selection against more virulent strains. Here we selected for high and low virulence within each of two clones of the rodent malaria parasite Plasmodium chabaudi on the basis of between-host differences in a surrogate measure of virulence--loss of live weight post-infection. Despite imposing strong selection for low virulence which mimicked 50-75% host mortality, the low virulence lines increased in virulence as much as the high virulence lines. Thus, artificial selection on between-host differences in virulence was unable to counteract natural selection for increased virulence caused by within-host selection processes. The parasite's asexual replication rate and number of sexual transmission forms also increased in all lines, consistent with evolutionary models explaining high virulence. An upper bound to virulence, though not the asexual replication rate, was apparent, but this bound was not imposed by host mortality. Thus, we found evidence of the factors assumed to drive evolution of increased virulence, but not those thought to counter this selection.
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