ArticleThe Journal of clinical investigation1999
Distinct roles of prostaglandin H synthases 1 and 2 in T-cell development.
Article in The Journal of clinical investigation, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 137 citations in OpenAlex.
- Drug-Induced Membranous Nephropathy: Piecing Together Clues to Understand Disease Mechanisms.Journal of the American Society of Nephrology : JASN · 2025Review
- Loci Associated With Antibody Response in Feral Swine (Frontiers in veterinary science · 2020Article
- Feline calicivirus- and murine norovirus-induced COX-2/PGE2 signaling pathway has proviral effects.PloS one · 2018Article
- Study of the role of cytosolic phospholipase A2 alpha in eicosanoid generation and thymocyte maturation in the thymus.PloS one · 2015Article
- B-cell development: COX-1 joins the game.Blood · 2014Article
- Polyunsaturated Fatty Acid-derived lipid mediators and T cell function.Frontiers in immunology · 2014Review
- Article
- Effects of treadmill exercise on neural stem cells, cell proliferation, and neuroblast differentiation in the subgranular zone of the dentate gyrus in cyclooxygenase-2 knockout mice.Neurochemical research · 2013Article
- Synthesis and biological evaluation of new benzo-thieno[3,2-d]pyrimidin-4-one sulphonamide thio-derivatives as potential selective cyclooxygenase-2 inhibitors.Molecular diversity · 2013Article
- Reciprocal crosstalk between dendritic cells and natural killer cells under the effects of PGE2 in immunity and immunopathology.Cellular & molecular immunology · 2013Review
- Cyclooxygenase-2 inhibits T helper cell type 9 differentiation during allergic lung inflammation via down-regulation of IL-17RB.American journal of respiratory and critical care medicine · 2013Article
- The immunobiology of prostanoid receptor signaling in connecting innate and adaptive immunity.BioMed research international · 2013Review
- Arachidonic acid accumulates in the stromal macrophages during thymus involution in diabetes.Histochemistry and cell biology · 2011Article
- Cyclooxygenase-2 regulates Th17 cell differentiation during allergic lung inflammation.American journal of respiratory and critical care medicine · 2011Article
- Evaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping.Molecular pain · 2010Article
- Article
- Targeted deletions of cyclooxygenase-2 and atherogenesis in mice.Circulation · 2010Article
- Cyclooxygenase-1 orchestrates germinal center formation and antibody class-switch via regulation of IL-17.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Risk management profile of etoricoxib: an example of personalized medicine.Therapeutics and clinical risk management · 2008Article
- Arsenic trioxide inhibits ATRA-induced prostaglandin E2 and cyclooxygenase-1 in NB4 cells, a model of acute promyelocytic leukemia.Leukemia · 2008Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Prostaglandin G and H synthases, or cyclooxygenases (COXs), catalyze the formation of prostaglandins (PGs). Whereas COX-1 is diffusely expressed in lymphoid cells in embryonic day 15.5 thymus, COX-2 expression is sparse, apparently limited to stromal cells. By contrast, COX-2 is predominant in a subset of medullary stromal cells in three- to five-week-old mice. The isozymes also differ in their contributions to lymphocyte development. Thus, experiments with selective COX-1 inhibitors in thymic lobes from normal and recombinase-activating gene-1 knockout mice support a role for this isoform in the transition from CD4(-)CD8(-) double-negative (DN) to CD4(+)CD8(+) double-positive (DP). Concordant data were obtained in COX-1 knockouts. Pharmacological inhibition and genetic deletion of COX-2, by contrast, support its role during early thymocyte proliferation and differentiation and, later, during maturation of the CD4 helper T-cell lineage. PGE2, but not other PGs, can rescue the effects of inhibition of either isoform, although it acts through distinct EP receptor subtypes. COX-dependent PG generation may represent a mechanism of thymic stromal support for T-cell development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.