ArticleThe Journal of cell biology1999
Trafficking of Shigella lipopolysaccharide in polarized intestinal epithelial cells.
Article in The Journal of cell biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 54 citations in OpenAlex.
- Blueberries Reduce Palm Oil-Induced Metabolic Endotoxemia in an In Vitro Human Intestinal-Immune Cell Model.Molecular nutrition & food research · 2025Article
- Endotoxin-induced alterations of adipose tissue function: a pathway to bovine metabolic stress.Journal of animal science and biotechnology · 2024Review
- Ruminal acidosis, bacterial changes, and lipopolysaccharides.Journal of animal science · 2020Review
- Lipopolysaccharides transport during fat absorption in rodent small intestine.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Dose response of endotoxin on hepatocyte and muscle mitochondrial respiration in vitro.BioMed research international · 2015Article
- Direct engagement of TLR4 in invariant NKT cells regulates immune diseases by differential IL-4 and IFN-γ production in mice.PloS one · 2012Article
- Article
- Proinflammatory signal transduction pathway induced by Shigella flexneri porins in caco-2 cells.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2009Article
- Enhanced microscopic definition of Campylobacter jejuni 81-176 adherence to, invasion of, translocation across, and exocytosis from polarized human intestinal Caco-2 cells.Infection and immunity · 2008Article
- Pseudomonas aeruginosa induces membrane blebs in epithelial cells, which are utilized as a niche for intracellular replication and motility.Infection and immunity · 2008Article
- Intracellular recognition of lipopolysaccharide by toll-like receptor 4 in intestinal epithelial cells.The Journal of experimental medicine · 2003Article
- Toll-like receptor 4 resides in the Golgi apparatus and colocalizes with internalized lipopolysaccharide in intestinal epithelial cells.The Journal of experimental medicine · 2002Article
- Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithelium.The American journal of pathology · 2002Article
- The pathogenesis of Shigella flexneri infection: lessons from in vitro and in vivo studies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2000Review
- Interleukin-8 controls bacterial transepithelial translocation at the cost of epithelial destruction in experimental shigellosis.Infection and immunity · 1999Article
- Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bacterial lipopolysaccharide (LPS) at the apical surface of polarized intestinal epithelial cells was previously shown to be transported from the apical to the basolateral pole of the epithelium (Beatty, W.L., and P.J. Sansonetti. 1997. Infect. Immun. 65:4395-4404). The present study was designed to elucidate the transcytotic pathway of LPS and to characterize the endocytic compartments involved in this process. Confocal and electron microscopic analyses revealed that LPS internalized at the apical surface became rapidly distributed within endosomal compartments accessible to basolaterally internalized transferrin. This compartment largely excluded fluid-phase markers added at either pole. Access to the basolateral side of the epithelium subsequent to trafficking to basolateral endosomes occurred via exocytosis into the paracellular space beneath the intercellular tight junctions. LPS appeared to exploit other endocytic routes with much of the internalized LPS recycled to the original apical membrane. In addition, analysis of LPS in association with markers of the endocytic network revealed that some LPS was sent to late endosomal and lysosomal compartments.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.