ArticleAmerican journal of human genetics1999
Disequilibrium mapping of a quantitative-trait locus in an expanding population.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Genomic prediction in pigs using data from a commercial crossbred population: insights from the Duroc x (Landrace x Yorkshire) three-way crossbreeding system.Genetics, selection, evolution : GSE · 2023Article
- A Cautionary Note on the Effects of Population Stratification Under an Extreme Phenotype Sampling Design.Frontiers in genetics · 2019Article
- EPS-LASSO: test for high-dimensional regression under extreme phenotype sampling of continuous traits.Bioinformatics (Oxford, England) · 2018Article
- Analysis of Sequence Data Under Multivariate Trait-Dependent Sampling.Journal of the American Statistical Association · 2015Article
- Using haplotypes for the prediction of allelic identity to fine-map QTL: characterization and properties.Genetics, selection, evolution : GSE · 2014Article
- Deciphering the genetic blueprint behind Holstein milk proteins and production.Genome biology and evolution · 2014Article
- Quantitative trait analysis in sequencing studies under trait-dependent sampling.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Detecting rare variant effects using extreme phenotype sampling in sequencing association studies.Genetic epidemiology · 2013Article
- Impact on modes of inheritance and relative risks of using extreme sampling when designing genetic association studies.Annals of human genetics · 2013Article
- A unified framework for detecting rare variant quantitative trait associations in pedigree and unrelated individuals via sequence data.Human heredity · 2012Article
- Using extreme phenotype sampling to identify the rare causal variants of quantitative traits in association studies.Genetic epidemiology · 2011Article
- A simple bias correction in linear regression for quantitative trait association under two-tail extreme selection.Behavior genetics · 2011Article
- A powerful score test to detect positive selection in genome-wide scans.European journal of human genetics : EJHG · 2010Article
- Power of selective genotyping in genome-wide association studies of quantitative traits.BMC proceedings · 2009Article
- Linkage disequilibrium and population structure in wild and domesticated populations of Phaseolus vulgaris L.Evolutionary applications · 2009Article
- Selection of the most informative individuals from families with multiple siblings for association studies.Genetic epidemiology · 2009Article
- Genetic susceptibility to peripheral arterial disease: a dark corner in vascular biology.Arteriosclerosis, thrombosis, and vascular biology · 2007Review
- Efficient association mapping of quantitative trait loci with selective genotyping.American journal of human genetics · 2007Article
- Improved power offered by a score test for linkage disequilibrium mapping of quantitative-trait loci by selective genotyping.American journal of human genetics · 2006Article
- Assessing the power of tag SNPs in the mapping of quantitative trait loci (QTL) with extremal and random samples.BMC genetics · 2005Article
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Abstract
Linkage disequilibrium (LD) mapping can be successful if there is strong nonrandom association between marker alleles and an allele affecting a trait of interest. The principles of LD mapping of dichotomous traits are well understood, but less is known about LD mapping of a quantitative-trait locus (QTL). It is shown in this report that selective genotyping can increase the power to detect and map a rare allele of large effect at a QTL. Two statistical tests of the association between an allele and a quantitative character are proposed. These tests are approximately independent, so information from them can be combined. Analytic theory is developed to show that these two tests are effective in detecting the presence of a low-frequency allele with a relatively large effect on the character when the QTL is either already a candidate locus or closely linked to a marker locus that is in strong LD with the QTL. The latter situation is expected in a rapidly growing population in which the allele of large effect was present initially in one copy. Therefore, the proposed tests are useful under the same conditions as those for successful LD mapping of a dichotomous trait or disease. Simulations show that, for detection of the presence of a QTL, these tests are more powerful than a simple t-test. The tests also provide a basis for defining a measure of association, gamma, between a low-frequency allele at a putative QTL and a low-frequency allele at a marker locus.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.