ArticleAmerican journal of human genetics1999
Sibling-based tests of linkage and association for quantitative traits.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.American journal of human genetics · 2008Pooled it
- Pooling analysis of genetic data: the association of leptin receptor (LEPR) polymorphisms with variables related to human adiposity.Genetics · 2001Pooled it
- Genetic and physiologic analysis of the role of uncoupling protein 3 in human energy homeostasis.Diabetes · 1999Trial
- Article
- Permutation testing in the presence of polygenic variation.Genetic epidemiology · 2015Article
- Family-based association mapping in crop species.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2013Review
- Accurate and flexible power calculations on the spot: Applications to genomic research.Statistics and its interface · 2011Article
- Article
- Choice of study phenotype in osteoporosis genetic research.Journal of bone and mineral metabolism · 2009Review
- The VNTR 2 repeat in MAOA and delinquent behavior in adolescence and young adulthood: associations and MAOA promoter activity.European journal of human genetics : EJHG · 2008Article
- Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles.Human heredity · 2008Review
- Gene-lifecourse interaction for alcohol consumption in adolescence and young adulthood: five monoamine genes.American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics · 2007Article
- Contributions of the DAT1 and DRD2 genes to serious and violent delinquency among adolescents and young adults.Human genetics · 2007Article
- Article
- Genome-wide scan of reading ability in affected sibling pairs with attention-deficit/hyperactivity disorder: unique and shared genetic effects.Molecular psychiatry · 2004Article
- Genetic determinants of obesity-related lipid traits.Journal of lipid research · 2004Article
- Fine mapping of complex trait genes combining pedigree and linkage disequilibrium information: a Bayesian unified framework.Genetics · 2003Article
- Power and design considerations for a general class of family-based association tests: quantitative traits.American journal of human genetics · 2002Article
- Evidence for linkage and association with reading disability on 6p21.3-22.American journal of human genetics · 2002Article
- Role of genetics in osteoporosis.Endocrine · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The transmission/disequilibrium test (TDT) developed by Spielman et al. can be a powerful family-based test of linkage and, in some cases, a test of association as well as linkage. It has recently been extended in several ways; these include allowance for implementation with quantitative traits, allowance for multiple alleles, and, in the case of dichotomous traits, allowance for testing in the absence of parental data. In this article, these three extensions are combined, and two procedures are developed that offer valid joint tests of linkage and (in the case of certain sibling configurations) association with quantitative traits, with use of data from siblings only, and that can accommodate biallelic or multiallelic loci. The first procedure uses a mixed-effects (i.e., random and fixed effects) analysis of variance in which sibship is the random factor, marker genotype is the fixed factor, and the continuous phenotype is the dependent variable. Covariates can easily be accommodated, and the procedure can be implemented in commonly available statistical software. The second procedure is a permutation-based procedure. Selected power studies are conducted to illustrate the relative power of each test under a variety of circumstances.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.