ArticleAmerican journal of human genetics1999
Linkage-disequilibrium mapping of disease genes by reconstruction of ancestral haplotypes in founder populations.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 112 citations in OpenAlex.
- Article
- HaploShare: identification of extended haplotypes shared by cases and evaluation against controls.Genome biology · 2015Article
- A graphical weighted power improving multiplicity correction approach for SNP selections.Current genomics · 2014Article
- Holm multiple correction for large-scale gene-shape association mapping.BMC genetics · 2014Article
- A variable-sized sliding-window approach for genetic association studies via principal component analysis.Annals of human genetics · 2009Article
- A regression-based association test for case-control studies that uses inferred ancestral haplotype similarity.Annals of human genetics · 2009Article
- Article
- Association mapping via regularized regression analysis of single-nucleotide-polymorphism haplotypes in variable-sized sliding windows.American journal of human genetics · 2007Article
- Haplotype thinking in lung disease.Proceedings of the American Thoracic Society · 2007Review
- Evidence for novel loci for late-onset Parkinson's disease in a genetic isolate from the Netherlands.Human genetics · 2006Article
- Linkage disequilibrium and association studies in higher plants: present status and future prospects.Plant molecular biology · 2005Review
- Article
- Article
- Linkage disequilibrium mapping in the Newfoundland population: a re-evaluation of the refinement of the Bardet-Biedl syndrome 1 critical interval.Human genetics · 2005Article
- Haplotype structure and phenotypic associations in the chromosomal regions surrounding two Arabidopsis thaliana flowering time loci.Genetics · 2004Article
- A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.American journal of human genetics · 2004Article
- Prospects for whole genome linkage disequilibrium mapping in domestic dog breeds.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
- False discovery rate in linkage and association genome screens for complex disorders.Genetics · 2003Article
- On the identification of disease mutations by the analysis of haplotype similarity and goodness of fit.American journal of human genetics · 2003Article
- Hierarchical modeling of linkage disequilibrium: genetic structure and spatial relations.American journal of human genetics · 2003Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Linkage disequilibrium (LD) mapping may be a powerful means for genome screening to identify susceptibility loci for common diseases. A new statistical approach for detection of LD around a disease gene is presented here. This method compares the distribution of haplotypes in affected individuals versus that expected for individuals descended from a common ancestor who carried a mutation of the disease gene. Simulations demonstrate that this method, which we term "ancestral haplotype reconstruction" (AHR), should be powerful for genome screening of phenotypes characterized by a high degree of etiologic heterogeneity, even with currently available marker maps. AHR is best suited to application in isolated populations where affected individuals are relatively recently descended (< approximately 25 generations) from a common disease mutation-bearing founder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.