ArticleAmerican journal of human genetics1999
Assessing the feasibility of linkage disequilibrium methods for mapping complex traits: an initial screen for bipolar disorder loci on chromosome 18.
Article in American journal of human genetics, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 65 citations in OpenAlex.
- A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.Molecular psychiatry · 2005Trial
- Investigation of Maternal Effects, Maternal-Fetal Interactions, and Parent-of-Origin Effects (Imprinting) for Candidate Genes Positioned on Chromosome 18q21, in Probands with Schizophrenia and their First-Degree Relatives.Psychiatry investigation · 2019Article
- Article
- Family-based association study between SLC2A1, HK1, and LEPR polymorphisms with myelomeningocele in Chile.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- Genetics of bipolar disorder.Dialogues in clinical neuroscience · 2008Review
- TGFB-induced factor (TGIF): a candidate gene for psychosis on chromosome 18p.Molecular psychiatry · 2007Article
- Suggestive linkage of schizophrenia to 5p13 in Costa Rica.Molecular psychiatry · 2005Article
- A simple correction for multiple testing for single-nucleotide polymorphisms in linkage disequilibrium with each other.American journal of human genetics · 2004Article
- Genetic demography of Antioquia (Colombia) and the Central Valley of Costa Rica.Human genetics · 2003Article
- Genomewide linkage disequilibrium mapping of severe bipolar disorder in a population isolate.American journal of human genetics · 2002Article
- Fine-scale mapping of a locus for severe bipolar mood disorder on chromosome 18p11.3 in the Costa Rican population.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- Article
- Genetics of bipolar affective disorder.Current psychiatry reports · 2000Review
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Authors and funding
22 authors at 4 institutions in 3 countries.
Funding
Abstract
Linkage disequilibrium (LD) analysis has been promoted as a method of mapping disease genes, particularly in isolated populations, but has not yet been used for genome-screening studies of complex disorders. We present results of a study to investigate the feasibility of LD methods for genome screening using a sample of individuals affected with severe bipolar mood disorder (BP-I), from an isolated population of the Costa Rican central valley. Forty-eight patients with BP-I were genotyped for markers spaced at approximately 6-cM intervals across chromosome 18. Chromosome 18 was chosen because a previous genome-screening linkage study of two Costa Rican families had suggested a BP-I locus on this chromosome. Results of the current study suggest that LD methods will be useful for mapping BP-I in a larger sample. The results also support previously reported possible localizations (obtained from a separate collection of patients) of BP-I-susceptibility genes at two distinct sites on this chromosome. Current limitations of LD screening for identifying loci for complex traits are discussed, and recommendations are made for future research with these methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.