ArticleMolecular and cellular biology1999
Specificity of cyclin E-Cdk2, TFIIB, and E1A interactions with a common domain of the p300 coactivator.
Article in Molecular and cellular biology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 56 citations in OpenAlex.
- Proteomic Landscape of Tissue-Specific Cyclin E Functions in Vivo.PLoS genetics · 2016Article
- Transcriptional/epigenetic regulator CBP/p300 in tumorigenesis: structural and functional versatility in target recognition.Cellular and molecular life sciences : CMLS · 2013Review
- Increased expression of transcription initiation factor IIB after rat traumatic brain injury.Journal of molecular histology · 2011Article
- The interferon antagonist ML protein of thogoto virus targets general transcription factor IIB.Journal of virology · 2008Article
- Dysregulation of CREB binding protein triggers thrombin-induced proliferation of vascular smooth muscle cells.Molecular and cellular biochemistry · 2008Article
- Role of the N-terminal activation domain of the coiled-coil coactivator in mediating transcriptional activation by beta-catenin.Molecular endocrinology (Baltimore, Md.) · 2006Article
- Targeting of p300/CREB binding protein coactivators by simian virus 40 is mediated through p53.Journal of virology · 2006Article
- Transcriptional analysis of avian embryonic tissues following infection with avian infectious bronchitis virus.Virus research · 2005Article
- Cell cycle in mouse development.Oncogene · 2005Review
- Phosphorylation of progesterone receptor serine 400 mediates ligand-independent transcriptional activity in response to activation of cyclin-dependent protein kinase 2.Molecular and cellular biology · 2004Article
- Cell-type-specific binding of the transcription factor CREB to the cAMP-response element.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Article
- p300 is involved in formation of the TBP-TFIIA-containing basal transcription complex, TAC.The EMBO journal · 2003Article
- Fine tuning the transcriptional regulation of the CXCL1 chemokine.Progress in nucleic acid research and molecular biology · 2003Review
- Transcriptional activation by the oestrogen receptor alpha is modulated through inhibition of cyclin-dependent kinases.Oncogene · 2002Article
- A role for coactivators and histone acetylation in estrogen receptor alpha-mediated transcription initiation.The EMBO journal · 2001Article
- Differential control of transcription by DNA-bound cyclins.Molecular biology of the cell · 2001Article
- Epstein-Barr virus immediate-early protein BRLF1 interacts with CBP, promoting enhanced BRLF1 transactivation.Journal of virology · 2001Article
- Acetylation of adenovirus E1A regulates binding of the transcriptional corepressor CtBP.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Regulation of beta -catenin transformation by the p300 transcriptional coactivator.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The p300 and CREB binding protein (CBP) transcriptional coactivators interact with a variety of transcription factors and regulate their activity. Among the interactions that have been described, the COOH-terminal region of p300 binds to cyclin E-cyclin-dependent kinase 2 (cyclin E-Cdk2) and TFIIB, as well as to the E1A gene products of adenovirus. Inhibition of Cdk activity by Cdk inhibitors, such as p21 or p27, potentiates NF-kappaB activity and provides a mechanism to coordinate cell cycle progression with the transcription of genes expressed during growth arrest. In this report, we analyze the specific domains of p300 required for the binding of p300 to cyclin E-Cdk2, TFIIB, and E1A and the ability of these proteins to interact with p300, alone or in combination. 12S E1A, an inhibitor of p300-dependent transcription, reduces the binding of TFIIB, but not that of cyclin E-Cdk2, to p300. In contrast, 13S E1A, a pleiotropic transcriptional activator, does not inhibit TFIIB binding to p300, although it enhances the interaction of cyclin E-Cdk2 with p300. Modification of cyclin E-Cdk2 is most likely required for association with p300 since the interaction is observed only with cyclin E-Cdk2 purified from mammalian cells. Domain swap studies show that the cyclin homology domain of TFIIB is involved in interactions with p300, although the homologous region from cyclin E does not mediate this interaction. These findings suggest that p300 or CBP function is regulated by interactions of various proteins with a common coactivator domain.
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