ArticleGenome research1999
Genomic structure and comparative analysis of nine Fugu genes: conservation of synteny with human chromosome Xp22.2-p22.1.
Article in Genome research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Repertoire of Protein Kinases Encoded in the Genome of Takifugu rubripes.Comparative and functional genomics · 2012Article
- Kinetoplastid PPEF phosphatases: dual acylated proteins expressed in the endomembrane system of Leishmania.Molecular and biochemical parasitology · 2007Article
- Genomic analysis of a 1 Mb region near the telomere of Hessian fly chromosome X2 and avirulence gene vH13.BMC genomics · 2006Article
- CDKL5/STK9 is mutated in Rett syndrome variant with infantile spasms.Journal of medical genetics · 2005Article
- Rett syndrome: clinical review and genetic update.Journal of medical genetics · 2005Review
- Mutations of CDKL5 cause a severe neurodevelopmental disorder with infantile spasms and mental retardation.American journal of human genetics · 2004Article
- Disruption of the serine/threonine kinase 9 gene causes severe X-linked infantile spasms and mental retardation.American journal of human genetics · 2003Article
- Conservation of long-range synteny and microsynteny between the genomes of two distantly related nematodes.Genome biology · 2002Article
- Four-hundred million years of conserved synteny of human Xp and Xq genes on three Tetraodon chromosomes.Genome research · 2002Article
- Estimation of synteny conservation and genome compaction between pufferfish (Fugu) and human.Yeast (Chichester, England) · 2000Article
- Molecular cloning and characterization of the Fugu rubripes MEST/COPG2 imprinting cluster and chromosomal localization in Fugu and Tetraodon nigroviridis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2000Article
- Generation and analysis of 25 Mb of genomic DNA from the pufferfish Fugu rubripes by sequence scanning.Genome research · 1999Article
- Classical and molecular cytogenetics of the pufferfish Tetraodon nigroviridis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1999Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pufferfish Fugu rubripes has a compact 400-Mb genome that is approximately 7.5 times smaller than the human genome but contains a similar number of genes. Focusing on the distal short arm of the human X chromosome, we have studied the evolutionary conservation of gene orders in Fugu and man. Sequencing of 68 kb of Fugu genomic DNA identified nine genes in the following order: (SCML2)-STK9, XLRS1, PPEF-1, KELCH2, KELCH1, PHKA2, AP19, and U2AF1-RS2. Apart from an evolutionary inversion separating AP19 and U2AF1-RS2 from PHKA2, gene orders are identical in Fugu and man, and all nine human homologs map to the Xp22 band. All Fugu genes were found to be smaller than their human counterparts, but gene structures were mostly identical. These data suggest that genomic sequencing in Fugu is a powerful and economical strategy to predict gene orders in the human genome and to elucidate the structure of human genes.
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Registered trials
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