ArticleGenome research1999
Identification of putative programmed -1 ribosomal frameshift signals in large DNA databases.
Article in Genome research, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 73 citations in OpenAlex.
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- The human pandemic coronaviruses on the show: The spike glycoprotein as the main actor in the coronaviruses play.International journal of biological macromolecules · 2021Review
- Regulators of Viral Frameshifting: More Than RNA Influences Translation Events.Annual review of virology · 2020Review
- Ribosomal frameshifting and transcriptional slippage: From genetic steganography and cryptography to adventitious use.Nucleic acids research · 2016Review
- Cell cycle control (and more) by programmed -1 ribosomal frameshifting: implications for disease and therapeutics.Cell cycle (Georgetown, Tex.) · 2015Article
- Yeast telomere maintenance is globally controlled by programmed ribosomal frameshifting and the nonsense-mediated mRNA decay pathway.Translation (Austin, Tex.) · 2013Article
- On programmed ribosomal frameshifting: the alternative proteomes.Frontiers in genetics · 2012Article
- Control of gene expression by translational recoding.Advances in protein chemistry and structural biology · 2012Review
- rRNA pseudouridylation defects affect ribosomal ligand binding and translational fidelity from yeast to human cells.Molecular cell · 2011Article
- Endogenous ribosomal frameshift signals operate as mRNA destabilizing elements through at least two molecular pathways in yeast.Nucleic acids research · 2011Article
- KnotInFrame: prediction of -1 ribosomal frameshift events.Nucleic acids research · 2008Article
- Molluscan mobile elements similar to the vertebrate Recombination-Activating Genes.Biochemical and biophysical research communications · 2008Article
- Ornithine decarboxylase antizyme finder (OAF): fast and reliable detection of antizymes with frameshifts in mRNAs.BMC bioinformatics · 2008Article
- Identification of functional, endogenous programmed -1 ribosomal frameshift signals in the genome of Saccharomyces cerevisiae.Nucleic acids research · 2007Article
- Programmed Ribosomal Frameshifting Goes Beyond Viruses: Organisms from all three kingdoms use frameshifting to regulate gene expression, perhaps signaling a paradigm shift.Microbe (Washington, D.C.) · 2006Article
- Specific effects of ribosome-tethered molecular chaperones on programmed -1 ribosomal frameshifting.Eukaryotic cell · 2006Article
- Detecting overlapping coding sequences in virus genomes.BMC bioinformatics · 2006Article
- The gene of an archaeal alpha-L-fucosidase is expressed by translational frameshifting.Nucleic acids research · 2006Article
- ICDS database: interrupted CoDing sequences in prokaryotic genomes.Nucleic acids research · 2006Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The cis-acting elements that promote efficient ribosomal frameshifting in the -1 (5') direction have been well characterized in several viral systems. Results from many studies have convincingly demonstrated that the basic molecular mechanisms governing programmed -1 ribosomal frameshifting are almost identical from yeast to humans. We are interested in testing the hypothesis that programmed -1 ribosomal frameshifting can be used to control cellular gene expression. Toward this end, a computer program was designed to search large DNA databases for consensus -1 ribosomal frameshift signals. The results demonstrated that consensus programmed -1 ribosomal frameshift signals can be identified in a substantial number of chromosomally encoded mRNAs and that they occur with frequencies from two- to sixfold greater than random in all of the databases searched. A preliminary survey of the databases resulting from the computer searches found that consensus frameshift signals are present in at least 21 homologous genes from different species, 2 of which are nearly identical, suggesting evolutionary conservation of function. We show that four previously described missense alleles of genes that are linked to human diseases would disrupt putative programmed -1 ribosomal frameshift signals, suggesting that the frameshift signal may be involved in the normal expression of these genes. We also demonstrate that signals found in the yeast RAS1 and the human CCR5 genes were able to promote significant levels of programmed -1 ribosomal frameshifting. The significance of these frameshifting signals in controlling gene expression is not known, however.
Indexed as
Identifiers
10330121PMC310776W1921542770What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.