ArticleThe EMBO journal1999
Transcriptional repression of the yeast CHA1 gene requires the chromatin-remodeling complex RSC.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 90 citations in OpenAlex.
- Bromodomains regulate dynamic targeting of the PBAF chromatin-remodeling complex to chromatin hubs.Biophysical journal · 2022Article
- The RSC (Remodels the Structure of Chromatin) complex of Candida albicans shows compositional divergence with distinct roles in regulating pathogenic traits.PLoS genetics · 2020Article
- Article
- Histone hypoacetylation-activated genes are repressed by acetyl-CoA- and chromatin-mediated mechanism.Biochimica et biophysica acta · 2014Article
- Chromatin and transcription in yeast.Genetics · 2012Review
- MRN1 implicates chromatin remodeling complexes and architectural factors in mRNA maturation.PloS one · 2012Article
- Selective removal of promoter nucleosomes by the RSC chromatin-remodeling complex.Nature structural & molecular biology · 2011Article
- The RSC chromatin remodelling enzyme has a unique role in directing the accurate positioning of nucleosomes.The EMBO journal · 2011Article
- Nucleosome positioning and gene regulation: advances through genomics.Nature reviews. Genetics · 2009Review
- Recruitment of a chromatin remodelling complex by the Hog1 MAP kinase to stress genes.The EMBO journal · 2009Article
- BRD7, a novel PBAF-specific SWI/SNF subunit, is required for target gene activation and repression in embryonic stem cells.The Journal of biological chemistry · 2008Article
- RSC regulates nucleosome positioning at Pol II genes and density at Pol III genes.The EMBO journal · 2008Article
- Rsc4 connects the chromatin remodeler RSC to RNA polymerases.Molecular and cellular biology · 2006Article
- Ssn6-Tup1 requires the ISW2 complex to position nucleosomes in Saccharomyces cerevisiae.The EMBO journal · 2004Article
- Genetic analysis of RSC58, which encodes a component of a yeast chromatin remodeling complex, and interacts with the transcription factor Swi6.Molecular genetics and genomics : MGG · 2004Article
- An array of coactivators is required for optimal recruitment of TATA binding protein and RNA polymerase II by promoter-bound Gcn4p.Molecular and cellular biology · 2004Article
- Tandem bromodomains in the chromatin remodeler RSC recognize acetylated histone H3 Lys14.The EMBO journal · 2004Article
- The yeast RSC chromatin-remodeling complex is required for kinetochore function in chromosome segregation.Molecular and cellular biology · 2003Article
- Global and specific transcriptional repression by the histone H3 amino terminus in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- A multiplicity of coactivators is required by Gcn4p at individual promoters in vivo.Molecular and cellular biology · 2003Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotes, DNA is packaged into chromatin, a compact structure that must be disrupted when genes are transcribed by RNA polymerase II. For transcription to take place, chromatin is remodeled via nucleosome disruption or displacement, a fundamental transcriptional regulatory mechanism in eukaryotic organisms. Here we show that the yeast chromatin-remodeling complex, RSC (remodels the structure of chromatin), isolated on the basis of homology to the SWI/SNF complex, is required for proper transcriptional regulation and nucleosome positioning in the highly inducible CHA1 promoter. In the absence of Sth1p/Nps1p (a homolog of Swi2p/Snf2p) or of Swh3p (a homolog of Swi3p), expression of CHA1 in non-induced cells is increased to a level comparable with that of fully induced cells. Furthermore, in non-induced cells depleted for Sth1p/Nps1p or Swh3p, a nucleosome positioned over the TATA box of the CHA1 promoter is disrupted, an architectural change normally only observed during transcriptional induction. In addition, deletion of the gene-specific activator Cha4p did not affect derepression of CHA1 in cells depleted for Swh3p. Thus, CHA1 constitutes a target for the RSC complex, and we propose that RSC is essential for maintaining a repressive chromatin structure at the CHA1 promoter.
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