ArticleThe EMBO journal1999
A constitutively active G-protein-coupled receptor causes mating self-compatibility in the mushroom Coprinus.
Article in The EMBO journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed.
- Functional expression of opioid receptors and other human GPCRs in yeast engineered to produce human sterols.Nature communications · 2022Article
- Molecular Effects of Auto-Antibodies on Angiotensin II Type 1 Receptor Signaling and Cell Proliferation.International journal of molecular sciences · 2022Article
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- Multiple Pathways to Homothallism in Closely Related Yeast Lineages in the Basidiomycota.mBio · 2021Article
- Article
- Article
- New approaches in bioprocess-control: Consortium guidance by synthetic cell-cell communication based on fungal pheromones.Engineering in life sciences · 2018Review
- Activation of the Mating Pheromone Response Pathway ofMycobiology · 2018Article
- Gamete signalling underlies the evolution of mating types and their number.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2016Article
- Fruiting Body Formation in Volvariella volvacea Can Occur Independently of Its MAT-A-Controlled Bipolar Mating System, Enabling Homothallic and Heterothallic Life Cycles.G3 (Bethesda, Md.) · 2016Article
- Hydrophobin-Based Surface Engineering for Sensitive and Robust Quantification of Yeast Pheromones.Sensors (Basel, Switzerland) · 2016Article
- Artificial cell-cell communication as an emerging tool in synthetic biology applications.Journal of biological engineering · 2015Article
- Loss of constitutive activity is correlated with increased thermostability of the human adenosine A2A receptor.British journal of pharmacology · 2013Article
- Frizzled receptors signal through G proteins.Cellular signalling · 2013Article
- Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease.Microbiology and molecular biology reviews : MMBR · 2012Review
- Evidence for maintenance of sex determinants but not of sexual stages in red yeasts, a group of early diverged basidiomycetes.BMC evolutionary biology · 2011Article
- Fungal mating pheromones: choreographing the dating game.Fungal genetics and biology : FG & B · 2011Review
- A single mating-type locus composed of homeodomain genes promotes nuclear migration and heterokaryosis in the white-rot fungus Phanerochaete chrysosporium.Eukaryotic cell · 2011Article
- Sex in fungi.Annual review of genetics · 2011Review
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4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the mushroom Coprinus cinereus, the multiallelic B mating type genes are predicted to encode a large family of seven-transmembrane domain receptors and CaaX-modified pheromones. We have shown that a single amino acid change Q229P in transmembrane domain VI of one receptor confers a self-compatible mating phenotype. Using a heterologous yeast assay, we have demonstrated that this C.cinereus pheromone receptor is a G-protein-coupled receptor and that the Q229P mutation is constitutively activating. A C.cinereus pheromone precursor was processed to an active species specifically in yeast MATa cells and activated the co-expressed wild-type receptor. Yeast cells expressing the wild-type receptor were used to test the activity of synthetic peptides, enabling us to predict the structure of the mature C.cinereus pheromone and to show that the Q229P mutation does not compromise normal receptor function.
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