ArticleThe American journal of pathology1999
The development of M cells in Peyer's patches is restricted to specialized dome-associated crypts.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 94 citations in OpenAlex.
- Thymic Mimetic Cells: Ontogeny as Immunology.Annual review of cell and developmental biology · 2024Review
- Hnf4 activates mimetic-cell enhancers to recapitulate gut and liver development within the thymus.The Journal of experimental medicine · 2023Article
- Infection-generated electric field in gut epithelium drives bidirectional migration of macrophages.PLoS biology · 2019Article
- M Cells: Intelligent Engineering of Mucosal Immune Surveillance.Frontiers in immunology · 2019Review
- Induction of Colonic M Cells during Intestinal Inflammation.The American journal of pathology · 2016Article
- Visualization of the entire differentiation process of murine M cells: suppression of their maturation in cecal patches.Mucosal immunology · 2015Article
- Peculiar composition of epithelial cells in follicle-associated intestinal crypts of Peyer's patches in the rat small intestine.The Journal of veterinary medical science · 2014Article
- The functional maturation of M cells is dramatically reduced in the Peyer's patches of aged mice.Mucosal immunology · 2013Article
- Mucosal Immune System and M Cell-targeting Strategies for Oral Mucosal Vaccination.Immune network · 2012Article
- The Ets transcription factor Spi-B is essential for the differentiation of intestinal microfold cells.Nature immunology · 2012Article
- Convergent and divergent development among M cell lineages in mouse mucosal epithelium.Journal of immunology (Baltimore, Md. : 1950) · 2011Article
- Comparative analysis of EspF variants in inhibition of Escherichia coli phagocytosis by macrophages and inhibition of E. coli translocation through human- and bovine-derived M cells.Infection and immunity · 2011Article
- Novel antigen delivery technologies: a review.Drug delivery and translational research · 2011Article
- CCR6hiCD11c(int) B cells promote M-cell differentiation in Peyer's patch.International immunology · 2011Article
- Enhancing oral vaccine potency by targeting intestinal M cells.PLoS pathogens · 2010Review
- The identification of intestinal M cells in the sacculus rotundus and appendix of the Angora rabbit.Veterinary research communications · 2010Article
- RANKL is necessary and sufficient to initiate development of antigen-sampling M cells in the intestinal epithelium.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Intestinal M cells: the fallible sentinels?World journal of gastroenterology · 2007Review
- Improving M cell mediated transport across mucosal barriers: do certain bacteria hold the keys?Immunology · 2004Review
- Intestinal villous M cells: an antigen entry site in the mucosal epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is controversial whether the membranous (M) cells of the Peyer's patches represent a separate cell line or develop from enterocytes under the influence of lymphocytes on the domes. To answer this question, the crypts that produce the dome epithelial cells were studied and the distribution of M cells over the domes was determined in mice. The Ulex europaeus agglutinin was used to detect M cells in mouse Peyer's patches. Confocal microscopy with lectin-gold labeling on ultrathin sections, scanning electron microscopy, and laminin immuno-histochemistry were combined to characterize the cellular composition and the structure of the dome-associated crypts and the dome epithelium. In addition, the sites of lymphocyte invasion into the dome epithelium were studied after removal of the epithelium using scanning electron microscopy. The domes of Peyer's patches were supplied with epithelial cells that derived from two types of crypt: specialized dome-associated crypts and ordinary crypts differing not only in shape, size, and cellular composition but also in the presence of M cell precursors. When epithelial cells derived from ordinary crypts entered the domes, they formed converging radial strips devoid of M cells. In contrast to the M cells, the sites where lymphocytes invaded the dome epithelium were not arranged in radial strips, but randomly distributed over the domes. M cell development is restricted to specialized dome-associated crypts. Only dome epithelial cells that derive from these specialized crypts differentiate into M cells. It is concluded that M cells represent a separate cell line that is induced in the dome-associated crypts by still unknown, probably diffusible lymphoid factors.
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