ArticleThe American journal of pathology1999
DNA copy number changes in thyroid carcinoma.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 116 citations in OpenAlex.
- Identification of malignant cells in single-cell transcriptomics data.Communications biology · 2025Review
- Copy number amplification-induced overexpression of lncRNA LOC101927668 facilitates colorectal cancer progression by recruiting hnRNPD to disrupt RBM47/p53/p21 signaling.Journal of experimental & clinical cancer research : CR · 2024Article
- Genetic alterations in thyroid cancer mediating both resistance to BRAF inhibition and anaplastic transformation.Oncotarget · 2024Article
- Pathogenesis of cancers derived from thyroid follicular cells.Nature reviews. Cancer · 2023Review
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- Loss of Integrase Interactor 1 (INI1) Expression in a Subset of Differentiated Thyroid Cancer.Diagnostics (Basel, Switzerland) · 2020Article
- ClickGene: an open cloud-based platform for big pan-cancer data genome-wide association study, visualization and exploration.BioData mining · 2019Article
- The contribution of molecular pathology to the classification of thyroid tumors.Diagnostic histopathology (Oxford, England) · 2018Article
- cMYC expression in thyroid follicular cell-derived carcinomas: a role in thyroid tumorigenesis.Diagnostic pathology · 2017Article
- Role of CDKN2C Copy Number in Sporadic Medullary Thyroid Carcinoma.Thyroid : official journal of the American Thyroid Association · 2016Article
- Mutational burdens and evolutionary ages of thyroid follicular adenoma are comparable to those of follicular carcinoma.Oncotarget · 2016Article
- Radiation signatures in childhood thyroid cancers after the Chernobyl accident: possible roles of radiation in carcinogenesis.Cancer science · 2015Review
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- Heterochromatin protein 1 expression is reduced in human thyroid malignancy.Laboratory investigation; a journal of technical methods and pathology · 2014Article
- Recent progress of genome study for anaplastic thyroid cancer.Genomics & informatics · 2013Article
- Genomic dissection of Hurthle cell carcinoma reveals a unique class of thyroid malignancy.The Journal of clinical endocrinology and metabolism · 2013Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The genetic changes leading to thyroid cancer are poorly characterized. We studied DNA copy number changes by comparative genomic hybridization (CGH) in 69 primary thyroid carcinomas. In papillary carcinoma, DNA copy number changes were rare (3 of 26, 12%). The changes were all gains, and they were associated with old age (P = 0.01) and the presence of cervical lymph node metastases at presentation (P = 0.08). DNA copy number changes were much more frequent in follicular carcinoma (16 of 20, 80%) than in papillary carcinoma (P < 0.0001), and follicular carcinomas had more often deletions (13/20 versus 0/26, P < 0.0001). Loss of chromosome 22 was common in follicular carcinoma (n = 7, 35%), it was more often seen in widely invasive than in minimally invasive follicular carcinoma (54% versus 0%, P = 0.04), and it was associated with old age at presentation (P = 0.01). In three of the four patients with follicular carcinoma who died of cancer, the tumor had loss of chromosome 22. DNA copy number changes were found in 5 (50%) of the 10 medullary carcinomas studied. Four of these five carcinomas had deletions, and in two of them there was deletion of chromosome 22. Eleven (85%) of the thirteen anaplastic carcinomas investigated had DNA copy number changes, of which five had deletions, and one had deletion of chromosome 22. The most common gains in anaplastic carcinoma were in chromosomes 7p (p22-pter, 31%), 8q (q22-qter, 23%), and 9q (q34-qter, 23%). We conclude that DNA copy number changes are frequent in follicular, medullary, and anaplastic thyroid carcinoma but rare in papillary carcinoma when studied by CGH. Loss of chromosome 22 is particularly common in follicular carcinoma, and it is associated with the widely invasive type.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.