ArticleThe American journal of pathology1999
Synergistic enhancement of chemokine generation and lung injury by C5a or the membrane attack complex of complement.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
- Complement as a vital nexus of the pathobiological connectome for acute respiratory distress syndrome: An emerging therapeutic target.Frontiers in immunology · 2023Review
- The Crucial Role of PPARγ-Egr-1-Pro-Inflammatory Mediators Axis in IgG Immune Complex-Induced Acute Lung Injury.Frontiers in immunology · 2021Article
- The Cooperative Induction of CCL4 in Human Monocytic Cells by TNF-α and Palmitate Requires MyD88 and Involves MAPK/NF-κB Signaling Pathways.International journal of molecular sciences · 2019Article
- Anti-inflammatory interventions-what has worked, not worked, and what may work in the future.Translational research : the journal of laboratory and clinical medicine · 2016Article
- Reconciling the IPC and Two-Hit Models: Dissecting the Underlying Cellular and Molecular Mechanisms of Two Seemingly Opposing Frameworks.Journal of immunology research · 2015Review
- Bifunctional lipocalin ameliorates murine immune complex-induced acute lung injury.The Journal of biological chemistry · 2013Article
- Zonulin as prehaptoglobin2 regulates lung permeability and activates the complement system.American journal of physiology. Lung cellular and molecular physiology · 2013Article
- Immune complexes and late complement proteins trigger activation of Syk tyrosine kinase in human CD4(+) T cells.Clinical and experimental immunology · 2012Article
- Molecular mechanisms of inflammation and tissue injury after major trauma--is complement the "bad guy"?Journal of biomedical science · 2011Review
- T cell activation by terminal complex of complement and immune complexes.The Journal of biological chemistry · 2011Article
- C5a receptor enables participation of mast cells in immune complex arthritis independently of Fcγ receptor modulation.Arthritis and rheumatism · 2010Article
- Attenuation of IgG immune complex-induced acute lung injury by silencing C5aR in lung epithelial cells.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2009Article
- Upregulation of phagocyte-derived catecholamines augments the acute inflammatory response.PloS one · 2009Article
- Co-expression of alpha(1,3)galactosyltransferase and Bacillus thuringiensis PIPLC enhances hyperacute rejection of tumor cells.Cancer immunology, immunotherapy : CII · 2007Article
- Complement depletion enhances pulmonary inflammatory response after liver injury.Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract · 2006Article
- Role of C5 in the development of airway inflammation, airway hyperresponsiveness, and ongoing airway response.The Journal of clinical investigation · 2005Article
- C5a anaphylatoxin is a major regulator of activating versus inhibitory FcgammaRs in immune complex-induced lung disease.The Journal of clinical investigation · 2002Article
- Activator protein-1 activation in acute lung injury.The American journal of pathology · 2002Article
- Roles of the complement system in human neurodegenerative disorders: pro-inflammatory and tissue remodeling activities.Molecular neurobiology · 2002Review
- Inhibition of complement as a therapeutic approach in inflammatory central nervous system (CNS) disease.Molecular medicine (Cambridge, Mass.) · 1999Review
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Complement plays an important role in many acute inflammatory responses. In the current studies it was demonstrated that, in the presence of either C5a or sublytic forms of the complement-derived membrane attack complex (MAC), rat alveolar macrophages costimulated with IgG immune complexes demonstrated synergistic production of C-X-C (macrophage inflammatory protein-2 and cytokine-induced neutrophil chemoattractant) and C-C (macrophage inflammatory protein-1alpha and monocyte chemoattractant-1) chemokines. In the absence of the costimulus, C5a or MAC did not induce chemokine generation. In in vivo studies, C5a and MAC alone caused limited or no intrapulmonary generation of chemokines, but in the presence of a costimulus (IgG immune complexes) C5a and MAC caused synergistic intrapulmonary generation of C-X-C and C-C chemokines but not of tumor necrosis factor alpha. Under these conditions increased neutrophil accumulation occurred, as did lung injury. These observations suggest that C5a and MAC function synergistically with a costimulus to enhance chemokine generation and the intensity of the lung inflammatory response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.