ArticleThe American journal of pathology1999
Mapping of genetic deletions on the long arm of chromosome 4 in human esophageal adenocarcinomas.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 59 citations in OpenAlex.
- Prognostic Alternative Splicing Signatures in Esophageal Carcinoma.Cancer management and research · 2021Review
- Novel APC gene mutations associated with protein alteration in diffuse type gastric cancer.BMC medical genetics · 2017Article
- Article
- LOH analysis of genes around D4S2964 identifies ARD1B as a prognostic predictor of hepatocellular carcinoma.World journal of gastroenterology · 2010Article
- Tumor suppress genes screening analysis on 4q in sporadic colorectal carcinoma.World journal of gastroenterology · 2008Article
- Microsatellite alterations in phenotypically normal esophageal squamous epithelium and metaplasia-dysplasia-adenocarcinoma sequence.World journal of gastroenterology · 2008Article
- Alternative splicing of the FGF antisense gene: differential subcellular localization in human tissues and esophageal adenocarcinoma.Journal of molecular medicine (Berlin, Germany) · 2007Article
- Genetic alterations in primary gastric carcinomas correlated with clinicopathological variables by array comparative genomic hybridization.Journal of Korean medical science · 2006Article
- Functional evidence for a squamous cell carcinoma mortality gene(s) on human chromosome 4.Oncogene · 2002Article
- Molecular cytogenetic evaluation of gastric cardia adenocarcinoma and precursor lesions.The American journal of pathology · 2001Article
- Molecular biology of Barrett's adenocarcinoma.Annals of surgery · 2001Review
- Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients.Oncogene · 2000Article
- Chromosomal imbalances in Barrett's adenocarcinoma and the metaplasia-dysplasia-carcinoma sequence.The American journal of pathology · 2000Article
- Coculturing diverse clonal populations prevents the early-stage neoplastic progression that occurs in the separate clones.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Novel DNA copy number losses in chromosome 12q12--q13 in adenoid cystic carcinoma.Neoplasia (New York, N.Y.)Article
- A mortality gene(s) for the human adenocarcinoma line HeLa maps to a 130-kb region of human chromosome 4q22-q23.Neoplasia (New York, N.Y.)Article
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Authors and funding
3 authors at 2 institutions in 4 countries.
Funding
Abstract
Loss of the long arm of chromosome 4 has been identified previously as a common occurrence in adenocarcinomas of the esophagus and gastroesophageal junction by relatively low resolution genetic surveys. To better define the extent of 4q deletion in these neoplasms we isolated DNA from 29 primary carcinomas using microdissection, and used DNA obtained from xenografts of 14 carcinomas grown in immunodeficient mice in an assay of loss of heterozygosity of 25 polymorphic microsatellite markers distributed along the chromosomal arm. Two carcinomas exhibited widespread microsatellite instability and were excluded from deletion mapping. In the remaining 41 carcinomas, loss of heterozygosity was detected in 33 (80%). Twenty-three cancers showed complete or extensive reduction to homozygosity along the length of the long arm. Ten cancers had smaller discrete areas of loss and were principally useful in discerning three non-overlapping areas of consensus genetic deletion. Area 1 centered on marker D4S1534 at 4q21.1-22, area 2 centered on marker D4S620 at 4q32-33, and area 3 centered on marker D4S426 at 4q35. No known tumor suppressor genes map to these loci, but the frequent deletion of these areas in gastroesophageal carcinomas and in other carcinomas suggests that undiscovered tumor suppressor genes may reside here.
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