ArticleJournal of clinical microbiology1999
Density and molecular epidemiology of Aspergillus in air and relationship to outbreaks of Aspergillus infection.
Article in Journal of clinical microbiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 128 citations in OpenAlex.
- Chronic invasive sinus aspergillosis in immunocompetent hosts: a geographic comparison.Mycopathologia · 2010Pooled it
- Atti Le giornate della ricerca scientificae delle esperienze professionali dei giovani: Società Italiana di Igiene, Medicina Preventiva e Sanità Pubblica (SItI) Roma 20-21 dicembre 2019.Journal of preventive medicine and hygiene · 2020Article
- Monitoring of Particle Environmental Pollution and Fungal Isolations During Hospital Building-Work Activities in a Hematology Ward.Mediterranean journal of hematology and infectious diseases · 2019Article
- Seasonal variation of the dominant allergenic fungal aerosols - One year study from southern Indian region.Scientific reports · 2017Article
- PCR-Internal Transcribed Spacer (ITS) genes sequencing and phylogenetic analysis of clinical and environmental Aspergillus species associated with HIV-TB co infected patients in a hospital in Abeokuta, southwestern Nigeria.African health sciences · 2016Article
- Preliminary study of the fungal ecology at the haematology and medical-oncology ward in Bamako, Mali.Mycopathologia · 2014Article
- Isolate-dependent growth, virulence, and cell wall composition in the human pathogen Aspergillus fumigatus.PloS one · 2014Article
- Monitoring environmental Aspergillus spp. contamination and meteorological factors in a haematological unit.Mycopathologia · 2013Article
- Fungal spore concentrations in two haematopoietic stem cell transplantation (HSCT) units containing distinct air control systems.Epidemiology and infection · 2013Article
- Sinonasal risk factors for the development of invasive fungal sinusitis in hematological patients: Are they important?Allergy & rhinology (Providence, R.I.) · 2011Article
- Prophylaxis of invasive aspergillosis with voriconazole or caspofungin during building work in patients with acute leukemia.Haematologica · 2010Article
- [Requirements for hygiene in the medical care of immunocompromised patients. Recommendations from the Committee for Hospital Hygiene and Infection Prevention at the Robert Koch Institute (RKI)].Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz · 2010Article
- Invasive Aspergillus infections in allo-SCT recipients: environmental sampling, nasal and oral colonization and galactomannan testing.Bone marrow transplantation · 2010Article
- Infection control measures to prevent invasive mould diseases in hematopoietic stem cell transplant recipients.Mycopathologia · 2009Review
- Aspergillus fumigatus: principles of pathogenesis and host defense.Eukaryotic cell · 2007Review
- The utility of intensified environmental surveillance for pathogenic moulds in a stem cell transplantation ward during construction work to monitor the efficacy of HEPA filtration.Bone marrow transplantation · 2007Article
- Multilocus sequence typing of the pathogenic fungus Aspergillus fumigatus.Journal of clinical microbiology · 2007Article
- Antifungal susceptibility and pathogenic potential of environmental isolated filamentous fungi compared with colonizing agents in immunocompromised patients.Mycopathologia · 2005Article
- Risk factors for invasive aspergillosis in neutropenic patients with hematologic malignancies.Leukemia · 2005Article
- Genotyping of 44 isolates of Fusarium solani, the main agent of fungal keratitis in Brazil.Journal of clinical microbiology · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
After five patients were diagnosed with nosocomial invasive aspergillosis caused by Aspergillus fumigatus and A. flavus, a 14-month surveillance program for pathogenic and nonpathogenic fungal conidia in the air within and outside the University Hospital in Rotterdam (The Netherlands) was begun. A. fumigatus isolates obtained from the Department of Hematology were studied for genetic relatedness by randomly amplified polymorphic DNA (RAPD) analysis. This was repeated with A. fumigatus isolates contaminating culture media in the microbiology laboratory. The density of the conidia of nonpathogenic fungi in the outside air showed a seasonal variation: higher densities were measured during the summer, while lower densities were determined during the fall and winter. Hardly any variation was found in the numbers of Aspergillus conidia. We found decreasing numbers of conidia when comparing air from outside the hospital to that inside the hospital and when comparing open areas within the hospital to the closed department of hematology. The increase in the number of patients with invasive aspergillosis could not be explained by an increase in the number of Aspergillus conidia in the outside air. The short-term presence of A. flavus can only be explained by the presence of a point source, which was probably patient related. Genotyping A. fumigatus isolates from the department of hematology showed that clonally related isolates were persistently present for more than 1 year. Clinical isolates of A. fumigatus obtained during the outbreak period were different from these persistent clones. A. fumigatus isolates contaminating culture media were all genotypically identical, indicating a causative point source. Knowledge of the epidemiology of Aspergillus species is necessary for the development of strategies to prevent invasive aspergillosis. RAPD fingerprinting of Aspergillus isolates can help to determine the cause of an outbreak of invasive aspergillosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.