ArticleJournal of clinical microbiology1999
VP4 and VP7 genotyping of rotavirus samples recovered from infected children in Ireland over a 3-year period.
Article in Journal of clinical microbiology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Group A Rotavirus Detection and Genotype Distribution before and after Introduction of a National Immunisation Programme in Ireland: 2015-2019.Pathogens (Basel, Switzerland) · 2020Article
- Sequence analysis of human rotavirus strains: comparison of clinical isolates from Northern and Southern Italy.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Incidence of rotavirus infection in children with gastroenteritis attending Jos university teaching hospital, Nigeria.Virology journal · 2011Article
- Gastroenteritis by rotavirus in Spanish children. Analysis of the disease burden.European journal of pediatrics · 2008Article
- Mutated G4P[8] rotavirus associated with a nationwide outbreak of gastroenteritis in Nicaragua in 2005.Journal of clinical microbiology · 2007Article
- Real-time reverse transcription-PCR for detection of rotavirus and adenovirus as causative agents of acute viral gastroenteritis in children.Journal of clinical microbiology · 2006Article
- G-serotypes of group A rotaviruses in Pilsen region (Czechia).Folia microbiologica · 2006Article
- Surveillance study (2000 to 2001) of G- and P-type human rotaviruses circulating in South Korea.Journal of clinical microbiology · 2004Article
- Diversity of group A human rotavirus types circulating over a 4-year period in Madrid, Spain.Journal of clinical microbiology · 2004Article
- Surveillance of rotavirus strains in Rio de Janeiro, Brazil, from 1997 to 1999.Journal of clinical microbiology · 2003Article
- Application of restriction fragment length polymorphism analysis of VP7-encoding genes: fine comparison of Irish and global rotavirus isolates.Journal of clinical microbiology · 2002Article
- Genomic diversity of group A rotavirus strains infecting humans in eastern India.Journal of clinical microbiology · 2002Article
- Epidemiological patterns of rotaviruses causing severe gastroenteritis in young children throughout Australia from 1993 to 1996.Journal of clinical microbiology · 2001Article
- Molecular characterization of rotavirus in Ireland: detection of novel strains circulating in the population.Journal of clinical microbiology · 2000Article
- G and P genotyping of rotavirus strains circulating in france over a three-year period: detection of G9 and P[6] strains at low frequencies. The AZAY Group.Journal of clinical microbiology · 2000Article
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5 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Between September 1995 and August 1998, the incidence and diversity of the main human rotavirus genotypes (G1, G2, G3, and G4 and P[8], P[4], P[6], and P[9]) among Irish children were determined by using established and adapted reverse transcriptase PCR-based genotyping methods. From a total of 193 rotavirus-positive specimens collected from nine hospitals we successfully identified the P type in 182 (94%) of the samples and the G type in 165 (85.5%) of the samples. Only four samples could not be assigned a G or P type. Two P types existed in Ireland, P[8] (78%) and P[4] (16%), and their relative incidence varied over the 3 years of this study. No P[6] or P[9] types were detected. G1 was the most predominant G type (55%), and the incidences of G2, G3, and G4 isolates were 15.5, 1, and 11%, respectively. Three percent of the samples tested had a mixed G type. A P and G type was assigned to 158 (81.8%) of samples. Of the typeable samples, G1 P[8] was the most prevalent (65%), whereas G2 P[4] (17%), G3 P[8] (1%), G4 P[8] (12%), and mixed types (all G1/ G4 P[8]) (4%) were detected less frequently. In the third year a significant genotypic shift from G1 P[8] to G2 P[4] and G4 P[8] was observed. During the study, we noticed that the inclusion of random primers during cDNA synthesis greatly increased the specificity of the PCR typing assays. No correlation was seen between the contributing hospitals and a specific genotype. In conclusion, the coverage of infection given by the recently licensed tetravalent vaccine would be significantly high in Ireland, although future monitoring of genotypic changes among Irish isolates should be encouraged.
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