ArticleGenes & development1999
The bHLH gene Hes1 is essential for expansion of early T cell precursors.
Article in Genes & development, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 74 papers.
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Who cites it
74 citing papers in PubMed.
- Article
- HES1 regulates bone marrow mesenchymal stromal cell function by suppressing NFATc2-mediated inflammation.Haematologica · 2026Article
- Regulation of Tetraspanin CD63 in Chronic Myeloid Leukemia (CML): Single-Cell Analysis of Asymmetric Hematopoietic Stem Cell Division Genes.Bioengineering (Basel, Switzerland) · 2025Article
- HES1 is required for mouse fetal hematopoiesis.Stem cell research & therapy · 2024Article
- SARS-CoV-2 inflammation durably imprints memory CD4 T cells.Science immunology · 2024Article
- Inflammation durably imprints memory CD4+ T cells.bioRxiv : the preprint server for biology · 2023Article
- Fate of hematopoietic stem cells determined by Notch1 signaling (Review).Experimental and therapeutic medicine · 2022Review
- Evolving Roles of Notch Signaling in Cortical Development.Frontiers in neuroscience · 2022Review
- FANCD2 and HES1 suppress inflammation-induced PPARɣ to prevent haematopoietic stem cell exhaustion.British journal of haematology · 2021Article
- Genome-Wide Analysis IdentifiesFrontiers in cell and developmental biology · 2021Article
- Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Hes1 deficiency causes hematopoietic stem cell exhaustion.Stem cells (Dayton, Ohio) · 2020Article
- The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia.Cold Spring Harbor perspectives in medicine · 2020Review
- Mutant p53 antagonizes p63/p73-mediated tumor suppression via Notch1.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Phosphatase and tensin homolog-β-catenin signaling modulates regulatory T cells and inflammatory responses in mouse liver ischemia/reperfusion injury.Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society · 2017Article
- TNF-alpha and Notch signaling regulates the expression of HOXB4 and GATA3 during early T lymphopoiesis.In vitro cellular & developmental biology. Animal · 2016Article
- Article
- Repression of Ccr9 transcription in mouse T lymphocyte progenitors by the Notch signaling pathway.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Developmental gene networks: a triathlon on the course to T cell identity.Nature reviews. Immunology · 2014Review
- T cell development requires constraint of the myeloid regulator C/EBP-α by the Notch target and transcriptional repressor Hes1.Nature immunology · 2013Article
14 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice mutant for the bHLH gene Hes1, which is known to keep cells in a proliferative state, mostly lack thymus. Transfer of Hes1-null fetal liver cells into RAG2-null host mice normally reconstitutes B cells but fails to generate mature T cells in the thymus. In the reconstituted thymus, T cell differentiation is arrested at the CD4(-)CD8(-) double negative (DN) stage. Both the initial T cell receptor (TCR)-independent and the subsequent TCR-dependent selective expansion during the DN stage are severely affected. Thus, Hes1 is essential for the earliest thymocyte expansion in a cell-autonomous manner.
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Registered trials
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