ArticleBritish journal of pharmacology1999
Functional evidence of alpha1D-adrenoceptors in the vasculature of young and adult spontaneously hypertensive rats.
Article in British journal of pharmacology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 67 citations in OpenAlex.
- Corticosterone binds αHypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Adrenoceptor Desensitization: Current Understanding of Mechanisms.Pharmacological reviews · 2024Review
- Updates in the function and regulation of αBritish journal of pharmacology · 2019Review
- Novel Structural Approaches to Study GPCR Regulation.International journal of molecular sciences · 2016Review
- Carboxyl terminus-truncated α1D-adrenoceptors inhibit the ERK pathway.Naunyn-Schmiedeberg's archives of pharmacology · 2016Article
- Signaling properties of human alpha(1D)-adrenoceptors lacking the carboxyl terminus: intrinsic activity, agonist-mediated activation, and desensitization.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Phospholipase C-delta1 modulates sustained contraction of rat mesenteric small arteries in response to noradrenaline, but not endothelin-1.American journal of physiology. Heart and circulatory physiology · 2008Article
- Evidence for involvement of alpha1D-adrenoceptors in contraction of femoral resistance arteries using knockout mice.British journal of pharmacology · 2005Article
- Alpha1-adrenoceptor subtypes involved in vasoconstrictor responses to exogenous and neurally released noradrenaline in rat femoral resistance arteries.British journal of pharmacology · 2004Article
- The alpha(1D)-adrenergic receptor directly regulates arterial blood pressure via vasoconstriction.The Journal of clinical investigation · 2002Article
- Pathological role of a constitutively active population of alpha(1D)-adrenoceptors in arteries of spontaneously hypertensive rats.British journal of pharmacology · 2002Article
- Functional characterization of alpha(1)-adrenoceptor subtypes in human skeletal muscle resistance arteries.British journal of pharmacology · 2001Article
- Phosphorylation and desensitization of alpha1d-adrenergic receptors.The Biochemical journal · 2001Article
- Vascular alpha-1D-adrenoceptors are overexpressed in aorta of the aryl hydrocarbon receptor null mouse: role of increased angiotensin II.Autonomic & autacoid pharmacologyArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The role of alpha1D-adrenoceptors in the vasculature of spontaneously hypertensive (SHR) and normotensive Wistar Kyoto rats (WKY), of different ages was assessed in pithed rats by the use of the selective alpha1D-adrenoceptor antagonist BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]-ethyl]-8-azaspiro [4.5]decane-7,9-dione dihydrochloride). BMY 7378 displaced the pressor effect of phenylephrine in young pre-hypertensive pithed SHR rats, but produced no effect in young WKY rats (dose ratio of 3.4 and 1.6, respectively), while in adult rats BMY 7378 produced a greater shift in the phenylephrine response curve than in younger animals (dose ratio of 3.2 and 6.2 in WKY and SHR, respectively). The presence of alpha1D-adrenoceptors in the vasculature of pre-hypertensive rats, suggests its role in the pathogenesis/maintenance of increased blood pressure.
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