ArticleOncogene1999
RBP1 induces growth arrest by repression of E2F-dependent transcription.
Article in Oncogene, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
33 citing papers in PubMed, 74 citations in OpenAlex.
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- Differential gene expression during early development in recently evolved and sympatric Arctic charr morphs.PeerJ · 2018Article
- LINE-1 silencing by retinoblastoma proteins is effected through the nucleosomal and remodeling deacetylase multiprotein complex.BMC cancer · 2016Article
- Retinoblastoma-binding protein 1 has an interdigitated double Tudor domain with DNA binding activity.The Journal of biological chemistry · 2014Article
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- Structural insight into recognition of methylated histone tails by retinoblastoma-binding protein 1.The Journal of biological chemistry · 2012Article
- The seed nuclear proteome.Frontiers in plant science · 2012Article
- Epigenetic virtues of chromodomains.Critical reviews in biochemistry and molecular biology · 2011Review
- Structure and mechanisms of lysine methylation recognition by the chromodomain in gene transcription.Biochemistry · 2011Review
- Cyclin-dependent kinase-mediated phosphorylation of RBP1 and pRb promotes their dissociation to mediate release of the SAP30·mSin3·HDAC transcriptional repressor complex.The Journal of biological chemistry · 2011Article
- Retinoblastoma binding protein-1 (RBP1) is a Runx2 coactivator and promotes osteoblastic differentiation.BMC musculoskeletal disorders · 2010Article
- Identification of chromatin remodeling genes Arid4a and Arid4b as leukemia suppressor genes.Journal of the National Cancer Institute · 2008Article
- SIRT1 negatively regulates HDAC1-dependent transcriptional repression by the RBP1 family of proteins.Oncogene · 2008Article
- Alterations of BRMS1-ARID4A interaction modify gene expression but still suppress metastasis in human breast cancer cells.The Journal of biological chemistry · 2008Article
- Structure-function analysis of the retinoblastoma tumor suppressor protein - is the whole a sum of its parts?Cell division · 2007Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Growth arrest and cell cycle progression are regulated by the retinoblastoma tumour suppressor pRB and related proteins p130 and p107 that bind to and inhibit the E2F family of transcription factors. Although the precise mechanism of this inhibition remains to be established, previous studies indicated the presence of transcriptional repression activity in the 'pocket' of RB family members. We show here that RBP1, a known pRB pocket-binding protein, possesses transcriptional repression activity and associates with p130-E2F and pRB-E2F complexes specifically during growth arrest. Overexpression of RBP1 both inhibited E2F-dependent gene expression and suppressed cell growth. Thus repression of E2F-dependent transcription by RBP1 via RB family members may play a central role in inducing growth arrest.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.