ArticleNature neuroscience1999
Regulation of dense core release from neuroendocrine cells revealed by imaging single exocytic events.
Article in Nature neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
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Who cites it
62 citing papers in PubMed.
- Probing single molecule mechanical interactions of syntaxin 1A with native synaptobrevin 2 residing on a secretory vesicle.Cell calcium · 2022Article
- Gβγ SNARE Interactions and Their Behavioral Effects.Neurochemical research · 2019Review
- Effects of near infrared focused laser on the fluorescence of labelled cell membrane.Scientific reports · 2018Article
- Sex Steroids Influence Brain-Derived Neurotropic Factor Secretion From Human Airway Smooth Muscle Cells.Journal of cellular physiology · 2016Article
- The conundrum of the high-affinity NGF binding site formation unveiled?Biophysical journal · 2015Article
- Hyperpolarization-activated cyclic nucleotide-gated channels and cAMP-dependent modulation of exocytosis in cultured rat lactotrophs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Lumenal protein within secretory granules affects fusion pore expansion.Biophysical journal · 2014Article
- Syndapin 3 modulates fusion pore expansion in mouse neuroendocrine chromaffin cells.American journal of physiology. Cell physiology · 2014Article
- Post-fusion structural changes and their roles in exocytosis and endocytosis of dense-core vesicles.Nature communications · 2014Article
- A new role for myosin II in vesicle fission.PloS one · 2014Article
- Mechanisms of granule membrane recapture following exocytosis in intact mast cells.The Journal of biological chemistry · 2013Article
- Advances in studying phasic dopamine signaling in brain reward mechanisms.Frontiers in bioscience (Elite edition) · 2013Review
- cAMP-mediated stabilization of fusion pores in cultured rat pituitary lactotrophs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Multivesicular exocytosis in rat pancreatic beta cells.Diabetologia · 2012Article
- The extended granin family: structure, function, and biomedical implications.Endocrine reviews · 2011Review
- Munc18-1 tuning of vesicle merger and fusion pore properties.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Spatial regulation of exocytic site and vesicle mobilization by the actin cytoskeleton.PloS one · 2011Article
- Imaging of lytic granule exocytosis in CD8+ cytotoxic T lymphocytes reveals a modified form of full fusion.Cellular immunology · 2011Article
- Dynamin and myosin regulate differential exocytosis from mouse adrenal chromaffin cells.Cellular and molecular neurobiology · 2010Review
- Regulation of secretory granule size by the precise generation and fusion of unit granules.Journal of cellular and molecular medicine · 2010Review
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Using FM1-43 fluorescence, we have optically detected single exocytic and endocytic events in rat pituitary lactotrophs. About fifty discrete fluorescent spots abruptly appear around the entire surface of a cell bathed in FM1-43 and high-potassium saline. The spots, which also immunostain for prolactin, reflect the labeling of dense cores as well as membranes of exocytosed secretory granules. Stained cores are not released, but remain attached to the cell and are eventually endocytosed. However, in cells exposed to dopamine (or an analog, bromocriptine), the cores dissolve and are secreted after several seconds. Solubilization of dense cores is mediated through a reduction in cytoplasmic cyclic AMP. Thus, the composition of secretions from individual secretory granules is regulated.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.