ReviewImmunological reviews1999
Comparative genome organization of the major histocompatibility complex: lessons from the Felidae.
Review in Immunological reviews, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 62 citations in OpenAlex.
- An Exploratory Bioinformatic Investigation of Cats' Susceptibility to Coronavirus-Deriving Epitopes.Life (Basel, Switzerland) · 2024Article
- Genomic analyses show extremely perilous conservation status of African and Asiatic cheetahs (Acinonyx jubatus).Molecular ecology · 2022Article
- Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids.Frontiers in genetics · 2022Review
- Transmission pathways and spillover of an erythrocytic bacterial pathogen from domestic cats to wild felids.Ecology and evolution · 2018Article
- Organization and characteristics of the major histocompatibility complex class II region in the Yangtze finless porpoise (Neophocaena asiaeorientalis asiaeorientalis).Scientific reports · 2016Article
- Integrating Genomic Data Sets for Knowledge Discovery: An Informed Approach to Management of Captive Endangered Species.International journal of genomics · 2016Review
- Ancestry runs deeper than blood: the evolutionary history of ABO points to cryptic variation of functional importance.BioEssays : news and reviews in molecular, cellular and developmental biology · 2013Article
- Extensive variation at MHC DRB in the New Zealand sea lion (Phocarctos hookeri) provides evidence for balancing selection.Heredity · 2013Article
- The functional gene diversity in natural populations over postglacial areas: the shaping mechanisms behind genetic composition of longnose dace (Rhinichthys cataractae) in northeastern North America.Journal of molecular evolution · 2011Article
- Cheetah paradigm revisited: MHC diversity in the world's largest free-ranging population.Molecular biology and evolution · 2011Article
- MHC class I and MHC class II DRB gene variability in wild and captive Bengal tigers (Panthera tigris tigris).Immunogenetics · 2010Article
- Lineage pattern, trans-species polymorphism, and selection pressure among the major lineages of feline MHC-DRB peptide-binding region.Immunogenetics · 2010Article
- Polymorphism and selection in the major histocompatibility complex DRA and DQA genes in the family Equidae.Immunogenetics · 2009Article
- Plagues and adaptation: Lessons from the Felidae models for SARS and AIDS.Biological conservation · 2006Article
- The feline major histocompatibility complex is rearranged by an inversion with a breakpoint in the distal class I region.Immunogenetics · 2005Article
- Article
- Avian papillomaviruses: the parrot Psittacus erithacus papillomavirus (PePV) genome has a unique organization of the early protein region and is phylogenetically related to the chaffinch papillomavirus.BMC microbiology · 2002Article
- Genetic monomorphism of the second exon of the DRB1 gene in the major histocompatibility complex of the arctic fox of Mednyi Island (Alopex lagopus semenovi Ognev, 1931).Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mammalian major histocompatibility complex (MHC) has taught both immunologists and evolutionary biologists a great deal about the patterns and processes that have led to immune defenses. Driven principally by human and mouse studies, comparative MHC projects among other mammalian species offer certain advantages in connecting MHC genome characters to natural situations. We have studied the MHC in the domestic cat and in several wild species of Felidae. Our observations affirm class I and class II homology with other mammalian orders, derivative gene duplications during the Felidae radiation, abundant persistent trans-species allele polymorphism, recombination-derived amino acid motifs, and inverted ratios of non-synonymous to silent substitutions in the MHC peptide-binding regions, consistent with overdominant selection in class I and II genes. MHC diversity as quantified in population studies is a powerful barometer of historic demographic reduction for several endangered species including cheetahs, Asiatic lions, Florida panthers and tigers. In two cases (Florida panther and cheetah), reduced MHC variation may be contributing to uniform population sensitivity to emerging infectious pathogens. The Felidae species, nearly all endangered and monitored for conservation concerns, have allowed a glimpse of species adaptation, mediated by MHC divergence, using comparative inferences drawn from human and mouse models.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.