ArticleProceedings of the National Academy of Sciences of the United States of America1999
Trading force for speed: why superfast crossbridge kinetics leads to superlow forces.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 137 citations in OpenAlex.
- Predicting axial muscle-fibre strains in larval zebrafish.The Journal of experimental biology · 2026Article
- Eccentric Exercise and Muscle Damage: An Introductory Guide.Journal of functional morphology and kinesiology · 2026Review
- Male and female syringeal muscles exhibit superfast shortening velocities in zebra finches.The Journal of experimental biology · 2024Article
- A new organisational design in skeletal muscle fibres.Cell and tissue research · 2023Article
- Bats expand their vocal range by recruiting different laryngeal structures for echolocation and social communication.PLoS biology · 2022Article
- Correlated evolution between colour conspicuousness and drum speed in woodpeckers.Royal Society open science · 2022Article
- One-to-one innervation of vocal muscles allows precise control of birdsong.Current biology : CB · 2021Article
- Sound production, hearing sensitivity, and in-depth study of the sound-producing muscles in the cowfish (Lactoria cornuta).Journal of anatomy · 2021Article
- Lysine acetylation of F-actin decreases tropomyosin-based inhibition of actomyosin activity.The Journal of biological chemistry · 2020Article
- Mechanical Characteristics of Ultrafast Zebrafish Larval Swimming Muscles.Biophysical journal · 2020Article
- Sex Steroids as Regulators of Gestural Communication.Endocrinology · 2020Review
- Altered Sarcomeric Structure and Function in Woody Breast Myopathy of Avian Pectoralis Major Muscle.Frontiers in physiology · 2020Article
- Molecular parallelism in fast-twitch muscle proteins in echolocating mammals.Science advances · 2018Article
- Scaling of sensorimotor delays in terrestrial mammals.Proceedings. Biological sciences · 2018Article
- Small CaThe Journal of general physiology · 2018Article
- Fundamental constraints in synchronous muscle limit superfast motor control in vertebrates.eLife · 2017Article
- Robust mechanobiological behavior emerges in heterogeneous myosin systems.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Skeletal Muscle Remodeling in Response to Eccentric vs. Concentric Loading: Morphological, Molecular, and Metabolic Adaptations.Frontiers in physiology · 2017Review
- Select forelimb muscles have evolved superfast contractile speed to support acrobatic social displays.eLife · 2016Article
- Knockdown of fast skeletal myosin-binding protein C in zebrafish results in a severe skeletal myopathy.The Journal of general physiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Superfast muscles power high-frequency motions such as sound production and visual tracking. As a class, these muscles also generate low forces. Using the toadfish swimbladder muscle, the fastest known vertebrate muscle, we examined the crossbridge kinetic rates responsible for high contraction rates and how these might affect force generation. Swimbladder fibers have evolved a 10-fold faster crossbridge detachment rate than fast-twitch locomotory fibers, but surprisingly the crossbridge attachment rate has remained unchanged. These kinetics result in very few crossbridges being attached during contraction of superfast fibers (only approximately 1/6 of that in locomotory fibers) and thus low force. This imbalance between attachment and detachment rates is likely to be a general mechanism that imposes a tradeoff of force for speed in all superfast fibers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.