ArticleProceedings of the National Academy of Sciences of the United States of America1999
Virus-inducible expression of a host chemokine gene relies on replication-linked mRNA stabilization.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 70 citations in OpenAlex.
- Cytokine expression in the colonic mucosa of human immunodeficiency virus-infected individuals before and during 9 months of antiretroviral therapy.Antimicrobial agents and chemotherapy · 2008Trial
- Constitutive activation of an epithelial signal transducer and activator of transcription (STAT) pathway in asthma.The Journal of clinical investigation · 1999Trial
- Modelling severe COVID-19 in TLR3-mutated hiPSCs-derived lung organoids.Cell death discovery · 2025Article
- Basal epithelial stem cells cross an alarmin checkpoint for postviral lung disease.The Journal of clinical investigation · 2021Article
- Antiviral IFN-γ responses of monocytes at birth predict respiratory tract illness in the first year of life.The Journal of allergy and clinical immunology · 2012Article
- Immune pathways for translating viral infection into chronic airway disease.Advances in immunology · 2009Review
- Pathophysiology of viral-induced exacerbations of COPD.International journal of chronic obstructive pulmonary disease · 2007Review
- IL-12 p80 is an innate epithelial cell effector that mediates chronic allograft dysfunction.American journal of respiratory and critical care medicine · 2006Article
- Role of CCL5 (RANTES) in viral lung disease.Journal of virology · 2006Article
- Chemokine complexity: the case for CCL5.American journal of respiratory cell and molecular biology · 2006Article
- Immunogenetic programs for viral induction of mucous cell metaplasia.American journal of respiratory cell and molecular biology · 2006Review
- CCL5-CCR5 interaction provides antiapoptotic signals for macrophage survival during viral infection.Nature medicine · 2005Article
- Dengue virus nonstructural protein NS5 induces interleukin-8 transcription and secretion.Journal of virology · 2005Article
- Acute and chronic airway responses to viral infection: implications for asthma and chronic obstructive pulmonary disease.Proceedings of the American Thoracic Society · 2005Review
- Defining and adjusting divergent host responses to viral infection.Immunologic research · 2005Review
- Viral induction of a chronic asthma phenotype and genetic segregation from the acute response.The Journal of clinical investigation · 2002Article
- Multiple cis regulatory elements control RANTES promoter activity in alveolar epithelial cells infected with respiratory syncytial virus.Journal of virology · 2001Article
- Interleukin 12 p40 production by barrier epithelial cells during airway inflammation.The Journal of experimental medicine · 2001Article
- Gene expression in epithelial cells in response to pneumovirus infection.Respiratory research · 2001Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Analysis of the host response to viral infection generally has focused on the capacity of viruses to activate or repress transcription of cellular genes, and this approach is also characteristic of work on RNA viruses such as respiratory syncytial virus (RSV). In the present study, it appeared initially that RSV-driven expression of a critical immune regulator, the beta-chemokine RANTES (regulated upon activation, normal T cell expressed and secreted), in primary-culture airway epithelial cells also depended on inducible gene transcription because expression was accompanied by coordinate increases in transcriptional initiation rate and gene promoter activity. However, RSV-driven increases in RANTES gene transcription and promoter activity were small and transient relative to RANTES expression, and they were no different in size and duration than for inactivated RSV that was incapable of fully inducing RANTES expression. These findings suggested that the increase in RANTES gene transcription was not sufficient for inducible expression and that critical regulatory effects occurred at a posttranscriptional level. This type of mechanism for virus-inducible expression of RANTES was established when we found that replicating (but not inactivated) RSV markedly increased RANTES mRNA half-life (from 0.8 to 6.8 h). In addition, RNase protection assays of heterologous promoter/reporter plasmids indicate that basal instability of RANTES mRNA is mediated at least in part by nucleotides 11-389 of the RANTES gene, and this region is also the target for induction by virus. The distinct pathway for production of RANTES (in combination with cytokine-dependent expression of RANTES and related immune-response genes) may more effectively coordinate immune cell interaction with epithelial barrier cells to mediate host defense.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.