ArticleProceedings of the National Academy of Sciences of the United States of America1999
A cell surface mucin specifically expressed in the midgut of the malaria mosquito Anopheles gambiae.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 71 citations in OpenAlex.
- Avian malaria and the overlooked metabolic pathways underlying mosquitoRoyal Society open science · 2025Article
- The fibrinolytic system enables the onset ofScience advances · 2021Article
- The Plasmodium bottleneck: malaria parasite losses in the mosquito vector.Memorias do Instituto Oswaldo Cruz · 2014Article
- Transcriptome sequencing and developmental regulation of gene expression in Anopheles aquasalis.PLoS neglected tropical diseases · 2014Article
- Fluazuron-induced morphophysiological changes in the cuticle formation and midgut of Rhipicephalus sanguineus Latreille, 1806 (Acari: Ixodidae) nymphs.Parasitology research · 2013Article
- A peroxidase/dual oxidase system modulates midgut epithelial immunity in Anopheles gambiae.Science (New York, N.Y.) · 2010Article
- Article
- The Anopheles gambiae adult midgut peritrophic matrix proteome.Insect biochemistry and molecular biology · 2009Article
- Differential gene expression in abdomens of the malaria vector mosquito, Anopheles gambiae, after sugar feeding, blood feeding and Plasmodium berghei infection.BMC genomics · 2006Article
- Glc1.8 from Microplitis demolitor bracovirus induces a loss of adhesion and phagocytosis in insect high five and S2 cells.Journal of virology · 2005Article
- Monoclonal antibody MG96 completely blocks Plasmodium yoelii development in Anopheles stephensi.Infection and immunity · 2003Article
- A targeted approach to the identification of candidate genes determining susceptibility to Plasmodium gallinaceum in Aedes aegypti.Molecular genetics and genomics : MGG · 2003Article
- Morphological studies on the extracellular structure of the midgut of a tick, Haemaphysalis longicornis (Acari: Ixodidae).Parasitology research · 2003Article
- Induction of mosquitocidal activity in mice immunized with Anopheles gambiae midgut cDNA.Infection and immunity · 2003Article
- Recombinantly expressed isoenzymic aminopeptidases from Helicoverpa armigera (American cotton bollworm) midgut display differential interaction with closely related Bacillus thuringiensis insecticidal proteins.The Biochemical journal · 2003Article
- Sex-specific and blood meal-induced proteins of Anopheles gambiae midguts: analysis by two-dimensional gel electrophoresis.Malaria journal · 2003Article
- The midgut epithelium of aquatic arthropods: a critical target organ in environmental toxicology.Environmental health perspectives · 2002Review
- Anopheles gambiae pilot gene discovery project: identification of mosquito innate immunity genes from expressed sequence tags generated from immune-competent cell lines.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An invertebrate intestinal mucin gene, AgMuc1, was isolated from the malaria vector mosquito Anopheles gambiae. The predicted 122-residue protein consists of a central core of seven repeating TTTTVAP motifs flanked by hydrophobic N- and C-terminal domains. This structure is similar to that of mucins that coat the protozoan parasite Trypanosoma cruzi. Northern blot analysis indicated that the gene is expressed exclusively in the midgut of adult mosquitoes. A length polymorphism and in situ hybridization were used to genetically and cytogenetically map AgMuc1 to division 7A of the right arm of the second chromosome. The subcellular localization of the encoded protein in tissue culture cells was examined by using a baculovirus vector to express AgMuc1 protein tagged with the green fluorescent protein (GFP). The results indicated that this protein is found at the cell surface and that both hydrophobic domains are required for cell surface targeting. We propose that AgMuc1 is an abundant mucin-like protein that lines the surface of the midgut microvilli, potentially protecting the intestinal epithelium from the proteinase-rich environment of the gut lumen. An intriguing possibility is that, as an abundant surface protein, AgMuc1 may also interact with the malaria parasite during its invasion of the mosquito midgut.
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