ArticleProceedings of the National Academy of Sciences of the United States of America1999
A high-density genome scan detects evidence for a bipolar-disorder susceptibility locus on 13q32 and other potential loci on 1q32 and 18p11.2.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 131 papers, 2 of them syntheses that pooled it.
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Who cites it
131 citing papers in PubMed, 2 syntheses or guidelines pooled it, 390 citations in OpenAlex.
- Genome scan meta-analysis of schizophrenia and bipolar disorder, part III: Bipolar disorder.American journal of human genetics · 2003Pooled it
- Meta-analysis of whole-genome linkage scans of bipolar disorder and schizophrenia.Molecular psychiatry · 2002Pooled it
- A genome-wide scan points to a susceptibility locus for bipolar disorder on chromosome 12.Molecular psychiatry · 2005Trial
- Shared and specific susceptibility loci for schizophrenia and bipolar disorder: a dense genome scan in Eastern Quebec families.Molecular psychiatry · 2005Trial
- Haplotypic association spanning the 22q11.21 genes COMT and ARVCF with schizophrenia.Molecular psychiatry · 2005Trial
- BDNF gene is a risk factor for schizophrenia in a Scottish population.Molecular psychiatry · 2005Trial
- A genome scan and follow-up study identify a bipolar disorder susceptibility locus on chromosome 1q42.Molecular psychiatry · 2004Trial
- Arginine-vasopressin systems in autistic phenotype schizophrenia: effect of a genetic variant of AVPR1a and AVPR1b.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Deletion of Fgf14 confers resilience to basal and stress-induced depressive-like behavior and reduces anxiety in mice.Translational psychiatry · 2025Article
- A Recessively Inherited Risk Locus on Chromosome 13q22-31 Conferring Susceptibility to Schizophrenia.Schizophrenia bulletin · 2021Article
- A Genome-Wide Association Study and Complex Network Identify Four Core Hub Genes in Bipolar Disorder.International journal of molecular sciences · 2017Article
- A promoter polymorphism rs2075824 within IMPA2 gene affecting the transcription activity: possible relationship with schizophrenia.Journal of cellular and molecular medicine · 2017Article
- Intracellular Fibroblast Growth Factor 14: Emerging Risk Factor for Brain Disorders.Frontiers in cellular neuroscience · 2017Review
- Polymorphisms of IKBKE gene are associated with major depressive disorder and panic disorder.Brain and behavior · 2015Article
- A significant risk locus on 19q13 for bipolar disorder identified using a combined genome-wide linkage and copy number variation analysis.BioData mining · 2015Article
- Genomic view of bipolar disorder revealed by whole genome sequencing in a genetic isolate.PLoS genetics · 2014Article
- Hypothesis of the neuroendocrine cortisol pathway gene role in the comorbidity of depression, type 2 diabetes, and metabolic syndrome.The application of clinical genetics · 2014Review
- Age-modulated association between prefrontal NAA and the BDNF gene.The international journal of neuropsychopharmacology · 2013Article
- Evidence for single nucleotide polymorphisms and their association with bipolar disorder.Neuropsychiatric disease and treatment · 2013Review
- Altered neurotransmitter release machinery in mice deficient for the deubiquitinating enzyme Usp14.American journal of physiology. Cell physiology · 2012Article
71 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
18 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipolar disorder is a severe mental illness characterized by mood swings of elation and depression. Family, twin, and adoption studies suggest a complex genetic etiology that may involve multiple susceptibility genes and an environmental component. To identify chromosomal loci contributing to vulnerability, we have conducted a genome-wide scan on approximately 396 individuals from 22 multiplex pedigrees by using 607 microsatellite markers. Multipoint nonparametric analysis detected the strongest evidence for linkage at 13q32 with a maximal logarithm of odds (lod) score of 3.5 (P = 0. 000028) under a phenotype model that included bipolar I, bipolar II with major depression, schizoaffective disorder, and recurrent unipolar disorder. Suggestive linkage was found on 1q31-q32 (lod = 2. 67; P = 0.00022) and 18p11.2 (lod = 2.32; P = 0.00054). Recent reports have linked schizophrenia to 13q32 and 18p11.2. Our genome scan identified other interesting regions, 7q31 (lod = 2.08; P = 0. 00099) and 22q11-q13 (lod = 2.1; P = 0.00094), and also confirmed reported linkages on 4p16, 12q23-q24, and 21q22. By comprehensive screening of the entire genome, we detected unreported loci for bipolar disorder, found support for proposed linkages, and gained evidence for the overlap of susceptibility regions for bipolar disorder and schizophrenia.
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