ArticleProceedings of the National Academy of Sciences of the United States of America1999
DNA sequence of the mitochondrial hypervariable region II from the neandertal type specimen.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed.
- Recent advances in methods to characterize archaic introgression in modern humans.Genome research · 2026Review
- Evolution of Homo in the Middle and Late Pleistocene.Journal of human evolution · 2022Review
- Determination of k-mer density in a DNA sequence and subsequent cluster formation algorithm based on the application of electronic filter.Scientific reports · 2021Article
- Inferring archaic introgression from hominin genetic data.Evolutionary anthropology · 2021Review
- Mitigating the effects of reference sequence bias in single-multiplex massively parallel sequencing of the mitochondrial DNA control region.Forensic science international. Genetics · 2019Article
- Out of Africa by spontaneous migration waves.PloS one · 2019Article
- ARIADNA: machine learning method for ancient DNA variant discovery.DNA research : an international journal for rapid publication of reports on genes and genomes · 2018Article
- Outstanding questions in the study of archaic hominin admixture.PLoS genetics · 2018Review
- Article
- Analysis of human mitochondrial DNA sequences from fecally polluted environmental waters as a tool to study population diversity.AIMS environmental science · 2017Article
- Archaeogenetics in evolutionary medicine.Journal of molecular medicine (Berlin, Germany) · 2016Review
- Denisovans, Melanesians, Europeans, and Neandertals: The Confusion of DNA Assumptions and the Biological Species Concept.Journal of molecular evolution · 2016Article
- Article
- Ancestry of modern Europeans: contributions of ancient DNA.Cellular and molecular life sciences : CMLS · 2013Review
- Ancient DNA studies: new perspectives on old samples.Genetics, selection, evolution : GSE · 2012Review
- To clone or not to clone: method analysis for retrieving consensus sequences in ancient DNA samples.PloS one · 2011Article
- Preferential access to genetic information from endogenous hominin ancient DNA and accurate quantitative SNP-typing via SPEX.Nucleic acids research · 2010Article
- Genetic identification of putative remains of the famous astronomer Nicolaus Copernicus.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Identification of skeletal remains of Communist Armed Forces victims during and after World War II: combined Y-chromosome (STR) and MiniSTR approach.Croatian medical journal · 2009Article
- A complete Neandertal mitochondrial genome sequence determined by high-throughput sequencing.Cell · 2008Article
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5 authors.
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Abstract
The DNA sequence of the second hypervariable region of the mitochondrial control region of the Neandertal type specimen, found in 1856 in central Europe, has been determined from 92 clones derived from eight overlapping amplifications performed from four independent extracts. When the reconstructed sequence is analyzed together with the previously determined DNA sequence from the first hypervariable region, the Neandertal mtDNA is found to fall outside a phylogenetic tree relating the mtDNAs of contemporary humans. The date of divergence between the mtDNAs of the Neandertal and contemporary humans is estimated to 465,000 years before the present, with confidence limits of 317,000 and 741,000 years. Taken together, the results support the concept that the Neandertal mtDNA evolved separately from that of modern humans for a substantial amount of time and lends no support to the idea that they contributed mtDNA to contemporary modern humans.
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