ArticleThe Journal of biological chemistry1999
Heterodimeric interactions between chicken ovalbumin upstream promoter-transcription factor family members ARP1 and ear2.
Article in The Journal of biological chemistry, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 38 citations in OpenAlex.
- Review
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- A proteomic analysis reveals that Snail regulates the expression of the nuclear orphan receptor Nuclear Receptor Subfamily 2 Group F Member 6 (Nr2f6) and interleukin 17 (IL-17) to inhibit adipocyte differentiation.Molecular & cellular proteomics : MCP · 2015Article
- The nuclear receptors COUP-TF: a long-lasting experience in forebrain assembly.Cellular and molecular life sciences : CMLS · 2014Review
- A signature motif mediating selective interactions of BCL11A with the NR2E/F subfamily of orphan nuclear receptors.Nucleic acids research · 2013Article
- Regulation of renin expression by the orphan nuclear receptors Nr2f2 and Nr2f6.American journal of physiology. Renal physiology · 2012Article
- Orphan nuclear receptors in breast cancer pathogenesis and therapeutic response.Endocrine-related cancer · 2010Review
- Web-based, participant-driven studies yield novel genetic associations for common traits.PLoS genetics · 2010Article
- A chicken ovalbumin upstream promoter transcription factor I (COUP-TFI) complex represses expression of the gene encoding tumor necrosis factor alpha-induced protein 8 (TNFAIP8).The Journal of biological chemistry · 2009Article
- Math1 target genes are enriched with evolutionarily conserved clustered E-box binding sites.Journal of molecular neuroscience : MN · 2006Article
- Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception.Genes & development · 2005Article
- COUP-TF (chicken ovalbumin upstream promoter transcription factor)-interacting protein 1 (CTIP1) is a sequence-specific DNA binding protein.The Biochemical journal · 2002Article
- Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors.The Journal of biological chemistry · 2000Article
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Members of the chicken ovalbumin upstream promoter-transcription factor (COUP-TF) subfamily of orphan nuclear receptors, which minimally includes COUP-TFI and ARP1, are highly expressed in brain and are generally considered to be constitutive repressors of transcription. We have used a yeast two-hybrid system to isolate proteins expressed in brain that interact with ARP1. One of the proteins isolated in this screen was Ear2, another orphan receptor that has been suggested to be a member of the COUP-TF subfamily. Here we demonstrate that ARP1 and Ear2 form heterodimers in solution and on directly repeated response elements with high efficiency and a specificity differing from that of homodimeric complexes composed of either receptor. ARP1 and Ear2 were observed to interact in mammalian cells, and the tissue distribution of Ear2 transcripts was found to overlap precisely with the expression pattern of ARP1 in several mouse tissues and embryonal carcinoma cell lines. Heterodimeric interactions between ARP1 and Ear2 may define a distinct pathway of orphan receptor signaling.
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