ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Enhancement of locomotor activity and conditioned reward to cocaine by brain-derived neurotrophic factor.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06550167 (Neuroprotective Effect of Omega), which is not on this map. Cited by 147 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neuroprotective Effect of Omega (Nano PSO), Changes in Neurotrophic BDNF and VEGF, and Their Association With Cognitive Status in Patients Who Used to Consume Psychoactive Substances
Who cites it
147 citing papers in PubMed, 1 synthesis or guideline pooled it, 375 citations in OpenAlex.
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- Levels of BDNF and NGF in adolescent rat hippocampus neonatally exposed to methamphetamine along with environmental alterations.Physiological research · 2023Article
- Opposing Spatially Segregated Function of Endogenous GDNF-RET Signaling in Cocaine Addiction.Biomolecules · 2023Article
- Distinctive Neuroanatomic Regions Involved in Cocaine-Induced Behavioral Sensitization in Mice.Biomedicines · 2023Article
- Voluntary Exercise Boosts Striatal Dopamine Release: Evidence for the Necessary and Sufficient Role of BDNF.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Role of nucleus accumbens microRNA-181a and MeCP2 in incubation of heroin craving in male rats.Psychopharmacology · 2021Article
- Growth Factors and Alcohol Use Disorder.Cold Spring Harbor perspectives in medicine · 2020Review
- The Role of Brain Derived Neurotrophic Factor in HIV-Associated Neurocognitive Disorder: From the Bench-Top to the Bedside.Neuropsychiatric disease and treatment · 2020Review
- Brain-Derived Neurotrophic Factor in the Nucleus Accumbens Mediates Individual Differences in Behavioral Responses to a Natural, Social Reward.Molecular neurobiology · 2020Article
- Accumbens brain-derived neurotrophic factor (BDNF) transmission inhibits cocaine seeking.Addiction biology · 2019Article
- Interactions of Glutamatergic Neurotransmission and Brain-Derived Neurotrophic Factor in the Regulation of Behaviors after Nicotine Administration.International journal of molecular sciences · 2019Review
- Uric acid enhances longevity and endurance and protects the brain against ischemia.Neurobiology of aging · 2019Article
- In silico identification and in vivo validation of miR-495 as a novel regulator of motivation for cocaine that targets multiple addiction-related networks in the nucleus accumbens.Molecular psychiatry · 2018Article
- Expression of brain-derived neurotrophic factors, neurotrophin-3, and neurotrophin-4 in the nucleus accumbens during heroin dependency and withdrawal.Neuroreport · 2017Article
- Reward Circuitry in Addiction.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Activation of Dopamine D1-D2 Receptor Complex Attenuates Cocaine Reward and Reinstatement of Cocaine-Seeking through Inhibition of DARPP-32, ERK, and ΔFosB.Frontiers in pharmacology · 2017Article
- Cross-talk between the epigenome and neural circuits in drug addiction.Progress in brain research · 2017Review
- Contingent and non-contingent recreational-like exposure to ethanol alters BDNF expression and signaling in the cortico-accumbal network differently.Psychopharmacology · 2016Article
- Effect of the sonic hedgehog receptor smoothened on the survival and function of dopaminergic neurons.Experimental neurology · 2016Article
- Systemic Delivery of a Brain-Penetrant TrkB Antagonist Reduces Cocaine Self-Administration and Normalizes TrkB Signaling in the Nucleus Accumbens and Prefrontal Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
87 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The mesolimbic dopamine (DA) system has been implicated in drug reward, locomotor sensitization, and responding for reward-related stimuli [termed conditioned reinforcers (CR)]. Here, we investigated the effect of brain-derived neurotrophic factor (BDNF), which enhances the survival and function of dopaminergic neurons, on stimulant-induced locomotor sensitization and responding for CR. In experiment 1, BDNF was infused into the nucleus accumbens (NAc) or ventral tegmental area over 2 weeks via chronically implanted minipumps (1-2.5 microgram/d), and the psychomotor stimulant effects of cocaine (5-15 mg/kg, i.p.) were studied. We found that BDNF enhanced the initial stimulant effects of cocaine and seemed to facilitate the development of sensitization to repeated cocaine doses. In experiment 2, we studied the effects of intra-NAc BDNF infusions on responding for CR. BDNF-treated rats showed twice as many CR responses compared with controls when saline was first administered. BDNF enhanced responding on the CR lever more than four times that seen in control animals after a cocaine injection (10 mg/kg, i.p.). The enhanced response to cocaine in BDNF-treated animals persisted for more than a month after the BDNF infusions had stopped, indicating long-lasting changes in the mesolimbic DA system caused by BDNF administration. In experiment 3, we examined locomotor sensitization to cocaine in heterozygous BDNF knock-out mice and found that the development of sensitization was delayed compared with wild-type littermates. These results demonstrate the profound effects of BDNF on the enhancement of both cocaine-induced locomotion and facilitation of CR and suggest a possible role for BDNF in long-term adaptations of the brain to cocaine.
Indexed as
Identifiers
10234039PMC6782687W1666851979What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.