ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Spontaneous activity in developing turtle retinal ganglion cells: pharmacological studies.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 61 citations in OpenAlex.
- Developmental synchrony of retinal waves, apoptosis, and angiogenesis in postnatal retina.eLife · 2026Article
- Ocular Necessities: A Neuroethological Perspective on Vertebrate Visual Development.Brain, behavior and evolution · 2024Review
- On the Role of LGN/V1 Spontaneous Activity as an Innate Learning Pattern for Visual Development.Frontiers in physiology · 2021Article
- Intrinsic and Synaptic Properties Shaping Diverse Behaviors of Neural Dynamics.Frontiers in computational neuroscience · 2020Article
- A biophysical model explains the spontaneous bursting behavior in the developing retina.Scientific reports · 2019Article
- The Effects of GABAergic Polarity Changes on Episodic Neural Network Activity in Developing Neural Systems.Frontiers in computational neuroscience · 2017Article
- An Evolutionarily Conserved Mechanism for Activity-Dependent Visual Circuit Development.Frontiers in neural circuits · 2016Review
- Following the ontogeny of retinal waves: pan-retinal recordings of population dynamics in the neonatal mouse.The Journal of physiology · 2014Article
- Role of emergent neural activity in visual map development.Current opinion in neurobiology · 2014Review
- Ionic mechanisms underlying tonic and phasic firing behaviors in retinal ganglion cells: a model study.Channels (Austin, Tex.) · 2014Article
- Vision drives correlated activity without patterned spontaneous activity in developing Xenopus retina.Developmental neurobiology · 2012Article
- EphA4 expression promotes network activity and spine maturation in cortical neuronal cultures.Neural development · 2011Article
- Non-cell-autonomous factor induces the transition from excitatory to inhibitory GABA signaling in retina independent of activity.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Article
- Early-stage waves in the retinal network emerge close to a critical state transition between local and global functional connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Retinal wave behavior through activity-dependent refractory periods.PLoS computational biology · 2007Article
- GABA type-A activity controls its own developmental polarity switch in the maturing retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Developmental modulation of retinal wave dynamics: shedding light on the GABA saga.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Potentiation of L-type calcium channels reveals nonsynaptic mechanisms that correlate spontaneous activity in the developing mammalian retina.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- The role of early neural activity in the maturation of turtle retinal function.Journal of anatomy · 2001Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
Abstract
Extracellular recordings were obtained from the ganglion cell (GC) layer during correlated spontaneous bursting activity (SBA) in the immature turtle retina. Pharmacological agents were bath-applied, and their effects on burst and correlation parameters were determined. SBA requires synaptic transmission. It was blocked in the presence of curare and mecamylamine, two cholinergic nicotinic antagonists, and enhanced with neostigmine, a cholinesterase inhibitor. SBA was profoundly inhibited during blockade of glutamatergic receptors with the broad spectrum antagonist kynurenate and it vanished with 6,7-dinitroquinoxaline-2-3-dione (DNQX) and 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), two AMPA/kainate receptor antagonists. Blockade of NMDA receptors with D(-)-2-amino-5-phosphonopentanoic acid (D-AP-5) led only to a modest reduction in SBA. Blockade of GABAA receptors with bicuculline prolonged the duration of the bursts. Inhibition of GABA uptake with nipecotic acid led to a decrease in burst rate. Blockade of K+ channels with cesium (Cs+) and tetraethylammonium (TEA) led to a dramatic decrease in excitability. Burst propagation between neighboring GCs was reduced by K+ channel blockade. Gap junction blockade had no consistent effect on bursts or correlation parameters. None of these drugs had a strong effect on the refractory period between bursts. We conclude that correlated SBA in immature turtle GCs requires both cholinergic nicotinic and glutamatergic (mainly through AMPA/kainate receptors) synaptic transmission. GABAergic activity modulates the intensity and the duration of the bursts. Extracellular K+ is involved in lateral activity propagation and increases retinal excitability, which may be required for burst generation.
Indexed as
Identifiers
10234019PMC6782712W2170605744What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.