ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience1999
Mapping quantitative trait loci for seizure response to a GABAA receptor inverse agonist in mice.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- A locus on mouse Ch10 influences susceptibility to limbic seizure severity: fine mapping and in silico candidate gene analysis.Genes, brain, and behavior · 2014Article
- Mapping genetic modifiers of survival in a mouse model of Dravet syndrome.Genes, brain, and behavior · 2014Article
- A large QTL for fear and anxiety mapped using an F2 cross can be dissected into multiple smaller QTLs.Genes, brain, and behavior · 2013Article
- Confirmation of an epilepsy modifier locus on mouse chromosome 11 and candidate gene analysis by RNA-Seq.Genes, brain, and behavior · 2012Article
- Article
- The genetic basis of adrenal gland weight and structure in BXD recombinant inbred mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- QTL analyses of temporal and intensity components of home-cage activity in KJR and C57BL/6J strains.BMC genetics · 2009Article
- An E3 ubiquitin ligase, Really Interesting New Gene (RING) Finger 41, is a candidate gene for anxiety-like behavior and beta-carboline-induced seizures.Biological psychiatry · 2009Article
- Acute and chronic responses to the convulsant pilocarpine in DBA/2J and A/J mice.Neuroscience · 2007Article
- Use of chromosome substitution strains to identify seizure susceptibility loci in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2007Article
- Fine mapping of a major locus on chromosome 10 for exploratory and fear-like behavior in mice.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Identification of a monogenic locus (jams1) causing juvenile audiogenic seizures in mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Voluntary ethanol consumption by mice: genome-wide analysis of quantitative trait loci and their interactions in a C57BL/6ByJ x 129P3/J F2 intercross.Genome research · 2002Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
Abstract
To define the genetic contributions affecting individual differences in seizure threshold, a beta carboline [methyl-beta-carboline-3-carboxylate (beta-CCM)]-induced model of generalized seizures was genetically dissected in mice. beta-CCM is a GABAA receptor inverse agonist and convulsant. By measuring the latency to generalized seizures after beta-CCM administration to A/J and C57BL6/J mice and their progeny, we estimated a heritability of 0.28 +/- 0.10. A genome wide screen in an F2 population of these parental strains (n = 273) mapped quantitative trait loci (QTLs) on proximal chromosome 7 [logarithm of the likelihood for linkage (LOD) = 3.71] and distal chromosome 10 (LOD = 4.29) for seizure susceptibility, explaining approximately 22 and 25%, respectively, of the genetic variance for this seizure trait. The best fitting logistic regression model suggests that the A/J allele at each locus increases the likelihood of seizures approximately threefold. In a subsequent backcross population (n = 223), we mapped QTLs on distal chromosome 4 (LOD = 2.88) and confirmed the distal chromosome 10 QTLs (LOD = 4.36). In the backcross, the C57BL/6J allele of the chromosome 10 QTL decreases the risk of seizures approximately twofold. These QTLs may ultimately lead to the identification of genes influencing individual differences in seizure threshold in mice and the discovery of novel anticonvulsant agents. The colocalization on distal chromosome 10 of a beta-CCM susceptibility QTL and a QTL for open field ambulation and vertical movement suggests the existence of a single, pleiotropic locus, which we have named Exq1.
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Identifiers
10234005PMC6782732W1642899901What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.