ArticleThe American journal of pathology1999
Developmental platelet endothelial cell adhesion molecule expression suggests multiple roles for a vascular adhesion molecule.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 49 citations in OpenAlex.
- PECAM/eGFP transgenic mice for monitoring of angiogenesis in health and disease.Scientific reports · 2018Article
- Control of leucocyte differentiation from embryonic stem cells upon vasculogenesis and confrontation with tumour tissue.Journal of cellular and molecular medicine · 2010Article
- Do current bladder smooth muscle cell isolation procedures result in a homogeneous cell population? Implications for bladder tissue engineering.World journal of urology · 2009Article
- The CMV early enhancer/chicken beta actin (CAG) promoter can be used to drive transgene expression during the differentiation of murine embryonic stem cells into vascular progenitors.BMC cell biology · 2008Article
- Epithelial cell adhesion molecule: more than a carcinoma marker and adhesion molecule.The American journal of pathology · 2007Review
- Spatial distribution and initial changes of SSEA-1 and other cell adhesion-related molecules on mouse embryonic stem cells before and during differentiation.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2004Article
- Adenovirus-based vascular endothelial growth factor gene delivery to human pancreatic islets.Gene therapy · 2004Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Platelet endothelial cell adhesion molecule (PECAM) is used extensively as a murine vascular marker. PECAM interactions have been implicated in both vasculogenesis and angiogenesis. To better understand the role of PECAM in mammalian development, PECAM expression was investigated during differentiation of murine embryonic stem (ES) cells and in early mouse embryos. Undifferentiated ES cells express PECAM, and as in vitro differentiation proceeds previously unidentified PECAM-positive cells that are distinct from vascular endothelial cells appear. PECAM expression is gradually restricted to endothelial cells and some hematopoietic cells of differentiated blood islands. In embryos, the preimplantation blastocyst contains PECAM-positive cells. PECAM expression is next documented in the postimplantation embryonic yolk sac, where clumps of mesodermal cells express PECAM before the development of mature blood islands. The patterns of PECAM expression suggest that undifferentiated cells, a prevascular cell type, and vascular endothelial cells express this marker during murine development. PECAM expression in blastocysts and by ES cells suggests that PECAM may function outside the vascular/hematopoietic lineage.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.