ArticleThe American journal of pathology1999
Linker for activation of T cells (LAT), a novel immunohistochemical marker for T cells, NK cells, mast cells, and megakaryocytes: evaluation in normal and pathological conditions.
Article in The American journal of pathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed.
- Disordered protein LAT encodes relative levels of signaling pathways in T cell activation.Science (New York, N.Y.) · 2026Article
- Article
- Gene expression profiles associated with early relapse during first remission induction in canine multicentric high-grade B-cell lymphoma.The Journal of veterinary medical science · 2024Article
- Identification of GC-rich LAT genes in birds.PloS one · 2023Article
- A role for GPI-CD59 in promoting T-cell signal transduction via LAT.Oncology letters · 2018Article
- SYK expression in monomorphic epitheliotropic intestinal T-cell lymphoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2018Article
- Identification of functional, short-lived isoform of linker for activation of T cells (LAT).Genes and immunity · 2014Article
- Aggressive mature natural killer cell neoplasms: from epidemiology to diagnosis.Orphanet journal of rare diseases · 2013Review
- Roles of histone hypoacetylation in LAT expression on T cells and Th2 polarization in allergic asthma.Journal of translational medicine · 2013Article
- A tale of two TRAPs: LAT and LAB in the regulation of lymphocyte development, activation, and autoimmunity.Immunologic research · 2011Review
- Transmembrane adaptor proteins in the high-affinity IgE receptor signaling.Frontiers in immunology · 2011Article
- LAB/NTAL/Lat2: a force to be reckoned with in all leukocytes?Journal of leukocyte biology · 2011Review
- The LAT story: a tale of cooperativity, coordination, and choreography.Cold Spring Harbor perspectives in biology · 2010Review
- Regulation of lymphocyte development and activation by the LAT family of adapter proteins.Immunological reviews · 2009Review
- Structurally distinct phosphatases CD45 and CD148 both regulate B cell and macrophage immunoreceptor signaling.Immunity · 2008Article
- Regulation of the human LAT gene by the Elf-1 transcription factor.BMC molecular biology · 2006Article
- Knock-in mutation of the distal four tyrosines of linker for activation of T cells blocks murine T cell development.The Journal of experimental medicine · 2001Article
- Review
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
LAT (linker for activation of T cells) is an integral membrane protein of 36-38 kd that plays an important role in T cell activation. Using a rabbit polyclonal antibody generated against the cytosolic portion of LAT, we investigated the immunohistochemical expression of LAT in normal and pathological hematolymphoid tissues. LAT reacts with human T cells in paraffin sections, including decalcified bone marrow trephines. LAT appears early in T cells at the thymocyte stage and before TdT expression in embryos, and is expressed in peripheral lymphoid tissues, without restriction to any T cell subpopulations. In addition to T cells, natural killer (NK) cells (evaluated with flow cytometry), megakaryocytes and mast cells are also LAT-positive, whereas B cells and other myeloid and monocytic derived cells are negative. Tested on a total of 264 paraffin-embedded tissue biopsies, LAT reacted with the great majority (96.8%) of T/NK-cell neoplasms, covering the full range of T cell maturation. Although antibodies to both LAT and CD3 had a similarly high sensitivity in the staining of T/NK-cell lymphomas, when used in conjunction, they successfully identified a higher number of cases (98.4%). Atypical megakaryocytes from different hematological disorders, as well as mast cells in mastocytosis were also LAT-positive, but all neoplasms of B cell origin, Hodgkin's lymphomas, and several nonlymphoid malignancies were negative. These data indicate that the anti-LAT antibody may be of value to diagnostic histopathologists for the identification of T cell neoplasms.
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