ArticleMolecular biology of the cell1999
Ras family GTPases control growth of astrocyte processes.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 68 citations in OpenAlex.
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- OXTR-mediated signaling in astrocytes contributes to anxiolysis.Molecular psychiatry · 2025Article
- Silactins and Structural Diversity of Biosilica in Sponges.Biomimetics (Basel, Switzerland) · 2024Article
- Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity.Cells · 2023Article
- PDGF-BB Preserves Mitochondrial Morphology, Attenuates ROS Production, and Upregulates Neuroglobin in an Astrocytic Model Under Rotenone Insult.Molecular neurobiology · 2018Article
- Dual observation of the ATP-evoked small GTPase activation and CaScientific reports · 2016Article
- The role of dimensionality in neuronal network dynamics.Scientific reports · 2016Article
- Article
- p120-catenin and β-catenin differentially regulate cadherin adhesive function.Molecular biology of the cell · 2013Article
- GluN3A: an NMDA receptor subunit with exquisite properties and functions.Neural plasticity · 2013Review
- Nanofibrillar scaffolds induce preferential activation of Rho GTPases in cerebral cortical astrocytes.International journal of nanomedicine · 2012Article
- Modulation of factors affecting optic nerve head astrocyte migration.Investigative ophthalmology & visual science · 2010Article
- Human myelin proteome and comparative analysis with mouse myelin.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- The pericyte: cellular regulator of microvascular blood flow.Microvascular research · 2009Review
- p120-catenin inhibits VE-cadherin internalization through a Rho-independent mechanism.Molecular biology of the cell · 2009Article
- Rho GTPases mediated integrin alpha v beta 3 activation in sphingosine-1-phosphate stimulated chemotaxis of endothelial cells.Histochemistry and cell biology · 2008Article
- Regulation of endothelial cell cytoskeletal reorganization by a secreted frizzled-related protein-1 and frizzled 4- and frizzled 7-dependent pathway: role in neovessel formation.The American journal of pathology · 2008Article
- Susceptibility to glaucoma: differential comparison of the astrocyte transcriptome from glaucomatous African American and Caucasian American donors.Genome biology · 2008Article
- Pericyte Rho GTPase mediates both pericyte contractile phenotype and capillary endothelial growth state.The American journal of pathology · 2007Article
- Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells.Histochemistry and cell biology · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Astrocytes in neuron-free cultures typically lack processes, although they are highly process-bearing in vivo. We show that basic fibroblast growth factor (bFGF) induces cultured astrocytes to grow processes and that Ras family GTPases mediate these morphological changes. Activated alleles of rac1 and rhoA blocked and reversed bFGF effects when introduced into astrocytes in dissociated culture and in brain slices using recombinant adenoviruses. By contrast, dominant negative (DN) alleles of both GTPases mimicked bFGF effects. A DN allele of Ha-ras blocked bFGF effects but not those of Rac1-DN or RhoA-DN. Our results show that bFGF acting through c-Ha-Ras inhibits endogenous Rac1 and RhoA GTPases thereby triggering astrocyte process growth, and they provide evidence for the regulation of this cascade in vivo by a yet undetermined neuron-derived factor.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.