ArticleMolecular biology of the cell1999
WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 32 citations in OpenAlex.
- Unique roles of tryptophanyl-tRNA synthetase in immune control and its therapeutic implications.Experimental & molecular medicine · 2019Review
- An Eye on Trafficking Genes: Identification of Four Eye Color Mutations in Drosophila.G3 (Bethesda, Md.) · 2016Article
- Pathogen-associated molecular patterns activate expression of genes involved in cell proliferation, immunity and detoxification in the amebocyte-producing organ of the snail Biomphalaria glabrata.Developmental and comparative immunology · 2016Article
- Overexpressed tryptophanyl-tRNA synthetase, an angiostatic protein, enhances oral cancer cell invasiveness.Oncotarget · 2015Article
- Review
- Organ-specific gene expression: the bHLH protein Sage provides tissue specificity to Drosophila FoxA.Development (Cambridge, England) · 2013Article
- Article
- Looking for organization patterns of highly expressed genes: purine-pyrimidine composition of precursor mRNAs.Journal of molecular evolution · 2007Article
- A new gamma-interferon-inducible promoter and splice variants of an anti-angiogenic human tRNA synthetase.Nucleic acids research · 2004Article
- An elongation factor-associating domain is inserted into human cysteinyl-tRNA synthetase by alternative splicing.Nucleic acids research · 2000Article
- Nucleolar localization of human methionyl-tRNA synthetase and its role in ribosomal RNA synthesis.The Journal of cell biology · 2000Article
- Aminoacyl-tRNA synthetases database Y2K.Nucleic acids research · 2000Article
- The complex of zinc bis-(2-methylphenoxyacetate) with tris-2(hydroxyethyl) amine as an activator of synthesis of total tryptophanyl-tRNA synthetase.Doklady. Biochemistry and biophysicsArticle
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
In a screen for genes expressed in the Drosophila embryonic salivary gland, we identified a tryptophanyl-tRNA synthetase gene that maps to cytological position 85D (WRS-85D). WRS-85D expression is dependent on the homeotic gene Sex combs reduced (Scr). In the absence of Scr function, WRS-85D expression is lost in the salivary gland primordia; conversely, ectopic expression of Scr results in expression of WRS-85D in new locations. Despite the fact that WRS-85D is a housekeeping gene essential for protein synthesis, we detected both WRS-85D mRNA and protein at elevated levels in the developing salivary gland. WRS-85D is required for embryonic survival; embryos lacking the maternal contribution were unrecoverable, whereas larvae lacking the zygotic component died during the third instar larval stage. We showed that recombinant WRS-85D protein specifically charges tRNATrp, and WRS-85D is likely to be the only tryptophanyl-tRNA synthetase gene in Drosophila. We characterized the expression patterns of all 20 aminoacyl-tRNA synthetases and found that of the four aminoacyl-tRNA synthetase genes expressed at elevated levels in the salivary gland primordia, WRS-85D is expressed at the highest level throughout embryogenesis. We also discuss the potential noncanonical activities of tryptophanyl-tRNA synthetase in immune response and regulation of cell growth.
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