ArticleMolecular biology of the cell1999
Radixin is involved in lamellipodial stability during nerve growth cone motility.
Article in Molecular biology of the cell, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 64 citations in OpenAlex.
- Radixin: Roles in the Nervous System and Beyond.Biomedicines · 2024Review
- Chromophore-Assisted Light Inactivation for Protein Degradation and Its Application in Biomedicine.Bioengineering (Basel, Switzerland) · 2024Review
- Control of actin polymerizationFrontiers in cell and developmental biology · 2022Review
- Moesin is involved in microglial activation accompanying morphological changes and reorganization of the actin cytoskeleton.The journal of physiological sciences : JPS · 2020Article
- Akt regulates neurite growth by phosphorylation-dependent inhibition of radixin proteasomal degradation.Scientific reports · 2018Article
- Sevoflurane Impairs Growth Cone Motility in Dissociated Murine Neurons.Journal of neurosurgical anesthesiology · 2016Article
- Building Blocks of Functioning Brain: Cytoskeletal Dynamics in Neuronal Development.International review of cell and molecular biology · 2016Review
- Anchoring of protein kinase A by ERM (ezrin-radixin-moesin) proteins is required for proper netrin signaling through DCC (deleted in colorectal cancer).The Journal of biological chemistry · 2015Article
- Ezrin mediates neuritogenesis via down-regulation of RhoA activity in cultured cortical neurons.PloS one · 2014Article
- Different modes of growth cone collapse in NG 108-15 cells.European biophysics journal : EBJ · 2013Article
- Radixin inhibition decreases adult neural progenitor cell migration and proliferation in vitro and in vivo.Frontiers in cellular neuroscience · 2013Article
- Chromophore-assisted laser inactivation in neural development.Neuroscience bulletin · 2012Review
- Activation of ezrin/radixin/moesin mediates attractive growth cone guidance through regulation of growth cone actin and adhesion receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Phosphorylation of ezrin/radixin/moesin proteins by LRRK2 promotes the rearrangement of actin cytoskeleton in neuronal morphogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- Dynamic length regulation of sensory stereocilia.Seminars in cell & developmental biology · 2008Review
- Interaction between telencephalin and ERM family proteins mediates dendritic filopodia formation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- The Nck-interacting kinase phosphorylates ERM proteins for formation of lamellipodium by growth factors.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- L1-mediated branching is regulated by two ezrin-radixin-moesin (ERM)-binding sites, the RSLE region and a novel juxtamembrane ERM-binding region.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- The neural cell adhesion molecules L1 and NCAM-180 act in different steps of neurite outgrowth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Immunocytochemistry and in vitro studies have suggested that the ERM (ezrin-radixin-moesin) protein, radixin, may have a role in nerve growth cone motility. We tested the in situ role of radixin in chick dorsal root ganglion growth cones by observing the effects of its localized and acute inactivation. Microscale chromophore-assisted laser inactivation (micro-CALI) of radixin in growth cones causes a 30% reduction of lamellipodial area within the irradiated region whereas all control treatments did not affect lamellipodia. Micro-CALI of radixin targeted to the middle of the leading edge often split growth cones to form two smaller growth cones during continued forward movement (>80%). These findings suggest a critical role for radixin in growth cone lamellipodia that is similar to ezrin function in pseudopodia of transformed fibroblasts. They are consistent with radixin linking actin filaments to each other or to the membrane during motility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.