ArticleBiophysical journal1999
Biomechanics of stretch-induced beading.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 41 citations in OpenAlex.
- The role of mechanics in axonal stability and development.Seminars in cell & developmental biology · 2023Review
- CROP: a retromer-PROPPIN complex mediating membrane fission in the endo-lysosomal system.The EMBO journal · 2022Article
- WIPI1 promotes fission of endosomal transport carriers and formation of autophagosomes through distinct mechanisms.Autophagy · 2021Article
- The Roles of Microtubules and Membrane Tension in Axonal Beading, Retraction, and Atrophy.Biophysical journal · 2019Article
- Characterization of neurite dystrophy after trauma by high speed structured illumination microscopy and lattice light sheet microscopy.Journal of neuroscience methods · 2019Article
- Article
- The role of the cytoskeleton in volume regulation and beading transitions in PC12 neurites.Biophysical journal · 2010Article
- Neurite beading is sufficient to decrease the apparent diffusion coefficient after ischemic stroke.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Cellular damage and prevention in childhood hydrocephalus.Brain pathology (Zurich, Switzerland) · 2004Review
- Prefission constriction of Golgi tubular carriers driven by local lipid metabolism: a theoretical model.Biophysical journal · 2003Article
- Membrane fusion: stalk model revisited.Biophysical journal · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To account for the beading of myelinated fibers, and axons of unmyelinated nerve fibers as well of neurites of cultured dorsal root ganglia caused by mild stretching, a model is presented. In this model, membrane tension and hydrostatic pressure are the basic factors responsible for axonal constriction, which causes the movement of axonal fluid from the constricted regions into the adjoining axon, there giving rise to the beading expansions. Beading ranges from a mild undulation, with the smallest degree of stretch, to more globular expansions and narrow intervening constrictions as stretch is increased: the degree of constriction is physically limited by the compaction of the cytoskeleton within the axons. The model is a general one, encompassing the possibility that the membrane skeleton, composed mainly of spectrin and actin associated with the inner face of the axolemma, could be involved in bringing about the constrictions and beading.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.