ArticleBiophysical journal1999
Biophysical integration of effects of epidermal growth factor and fibronectin on fibroblast migration.
Article in Biophysical journal, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
47 citing papers in PubMed, 156 citations in OpenAlex.
- Matrix metalloproteinase-9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells.FEBS open bio · 2026Article
- Directing Cell Phenotype: Quantitative Single-Cell Migration Assay Leveraging Tunable Extracellular Surfaces.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- KCTD4 interacts with CLIC1 to disrupt calcium homeostasis and promote metastasis in esophageal cancer.Acta pharmaceutica Sinica. B · 2023Article
- Multi-Cue Kinetic Model with Non-Local Sensing for Cell Migration on a Fiber Network with Chemotaxis.Bulletin of mathematical biology · 2022Article
- Computational model of wound healing: EGF secreted by fibroblasts promotes delayed re-epithelialization of epithelial keratinocytes.Integrative biology : quantitative biosciences from nano to macro · 2018Article
- Cell migration on material-driven fibronectin microenvironments.Biomaterials science · 2017Article
- Ring-Shaped Microlanes and Chemical Barriers as a Platform for Probing Single-Cell Migration.Scientific reports · 2016Article
- How does the pathophysiological context influence delivery of bone growth factors?Advanced drug delivery reviews · 2015Review
- Combined epidermal growth factor receptor and Beclin1 autophagic protein expression analysis identifies different clinical presentations, responses to chemo- and radiotherapy, and prognosis in glioblastoma.BioMed research international · 2015Article
- RhoC mediates epidermal growth factor-stimulated migration and invasion in head and neck squamous cell carcinoma.Neoplasia (New York, N.Y.) · 2015Article
- Geometric control of cell migration.Scientific reports · 2013Article
- Effects of adipose stem cell-conditioned medium on the migration of vascular endothelial cells, fibroblasts and keratinocytes.Experimental and therapeutic medicine · 2013Article
- Regulation of integrin adhesions by varying the density of substrate-bound epidermal growth factor.Biointerphases · 2012Article
- Substrate elasticity modulates TGF beta stimulated re-differentiation of expanded human articular chondrocytes.Drug delivery and translational research · 2012Article
- Engineering microscale topographies to control the cell-substrate interface.Biomaterials · 2012Review
- Differences in adhesion and protrusion properties correlate with differences in migration speed under EGF stimulation.BMC biophysics · 2012Article
- Bone morphogenetic protein-2-induced signaling and osteogenesis is regulated by cell shape, RhoA/ROCK, and cytoskeletal tension.Stem cells and development · 2012Article
- Modular design of micropattern geometry achieves combinatorial enhancements in cell motility.Langmuir : the ACS journal of surfaces and colloids · 2012Article
- β3 integrin-EGF receptor cross-talk activates p190RhoGAP in mouse mammary gland epithelial cells.Molecular biology of the cell · 2011Article
- Controlling multipotent stromal cell migration by integrating "course-graining" materials and "fine-tuning" small molecules via decision tree signal-response modeling.Biomaterials · 2011Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
Cell migration is regulated simultaneously by growth factors and extracellular matrix molecules. Although information is continually increasing regarding the relevant signaling pathways, there exists little understanding concerning how these pathways integrate to produce the biophysical processes that govern locomotion. Herein, we report the effects of epidermal growth factor (EGF) and fibronectin (Fn) on multiple facets of fibroblast motility: locomotion speed, membrane extension and retraction activity, and adhesion. A surprising finding is that EGF can either decrease or increase locomotion speed depending on the surface Fn concentration, despite EGF diminishing global cell adhesion at all Fn concentrations. At the same time, the effect of EGF on membrane activity varies from negative to positive to no-effect as Fn concentration and adhesion range from low to high. Taking these effects together, we find that EGF and Fn regulate fibroblast migration speed through integration of the processes of membrane extension, attachment, and detachment, with each of these processes being rate-limiting for locomotion in sequential regimes of increasing adhesivity. Thus, distinct biophysical processes are shown to integrate for overall cell migration responses to growth factor and extracellular matrix stimuli.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.