ArticleNeuron1999
The Drosophila dCREB2 gene affects the circadian clock.
Article in Neuron, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
65 citing papers in PubMed, 141 citations in OpenAlex.
- Mutual coupling of neurons in the circadian master clock: What we can learn from fruit flies.Neurobiology of sleep and circadian rhythms · 2025Article
- Reassessing the involvement of the CREB pathway in the circadian clock of Drosophila melanogaster.Npj biological timing and sleep · 2024Article
- Methylxanthines Modulate Circadian Period Length Independently of the Action of Phosphodiesterase.Microbiology spectrum · 2023Article
- Integration of Circadian Clock Information in theJournal of biological rhythms · 2021Review
- Involvement ofFrontiers in physiology · 2021Article
- An in vivo RNAi screen uncovers the role of AdoR signaling and adenosine deaminase in controlling intestinal stem cell activity.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The eIF2α Kinase GCN2 Modulates Period and Rhythmicity of the Circadian Clock by Translational Control of Atf4.Neuron · 2019Article
- Drosophila CrebB is a Substrate of the Nonsense-Mediated mRNA Decay Pathway that Sustains Circadian Behaviors.Molecules and cells · 2019Article
- The Phosphorylation of CREB at Serine 133 Is a Key Event for Circadian Clock Timing and Entrainment in the Suprachiasmatic Nucleus.Journal of biological rhythms · 2018Article
- Calcium and cAMP directly modulate the speed of the Drosophila circadian clock.PLoS genetics · 2018Article
- Nonreciprocal homeostatic compensation inJournal of neurophysiology · 2017Article
- Central and peripheral clocks are coupled by a neuropeptide pathway in Drosophila.Nature communications · 2017Article
- Article
- CRTC Potentiates Light-independent timeless Transcription to Sustain Circadian Rhythms in Drosophila.Scientific reports · 2016Article
- Neuronal energy-sensing pathway promotes energy balance by modulating disease tolerance.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Early-onset sleep defects in Drosophila models of Huntington's disease reflect alterations of PKA/CREB signaling.Human molecular genetics · 2016Article
- Notch Intracellular Domain (NICD) Suppresses Long-Term Memory Formation in Adult Drosophila Flies.Cellular and molecular neurobiology · 2015Article
- Spatio-temporal in vivo recording of dCREB2 dynamics in Drosophila long-term memory processing.Neurobiology of learning and memory · 2015Article
- Circadian Clock Dysfunction and Psychiatric Disease: Could Fruit Flies have a Say?Frontiers in neurology · 2015Review
- Control of lipid metabolism by tachykinin in Drosophila.Cell reports · 2014Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We report the role of dCREB2, the Drosophila homolog of CREB/CREM, in circadian rhythms. dCREB2 activity cycles with a 24 hr rhythm in flies, both in a light:dark cycle and in constant darkness. A mutation in dCREB2 shortens circadian locomotor rhythm in flies and dampens the oscillation of period, a known clock gene. Cycling dCREB2 activity is abolished in a period mutant, indicating that dCREB2 and Period affect each other and suggesting that the two genes participate in the same regulatory feedback loop. We propose that dCREB2 supports cycling of the Period/Timeless oscillator. These findings support CREB's role in mediating adaptive behavioral responses to a variey of environmental stimuli (stress, growth factors, drug addiction, circadian rhythms, and memory formation) in mammals and long-term memory formation and circadian rhythms in Drosophila.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.