ReviewEnvironmental health perspectives1999
Cholinesterases in neural development: new findings and toxicologic implications.
Review in Environmental health perspectives, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 99 citations in OpenAlex.
- Comparative Hepatic Toxicity of Pesticides in Common Carp (Journal of xenobiotics · 2026Article
- A drug repurposing screen reveals dopamine signaling as a critical pathway underlying potential therapeutics for the rare disease DPAGT1-CDG.PLoS genetics · 2024Article
- Cholinesterases and the fine line between poison and remedy.Biochemical pharmacology · 2018Review
- Erythrocyte acetylcholinesterase as biomarker of pesticide exposure: new and forgotten insights.Environmental science and pollution research international · 2018Review
- Bioconcentration and effects of hexabromocyclododecane exposure in crucian carp (Carassius auratus).Ecotoxicology (London, England) · 2018Article
- Effects of Chlorpyrifos or Methyl Parathion on Regional Cholinesterase Activity and Muscarinic Receptor Subtype Binding in Juvenile Rat Brain.Journal of toxicology and pharmacology · 2017Article
- Zebrafish as a model for acetylcholinesterase-inhibiting organophosphorus agent exposure and oxime reactivation.Annals of the New York Academy of Sciences · 2016Review
- Characterization of catalytic efficiency parameters of brain cholinesterases in tropical fish.Fish physiology and biochemistry · 2014Article
- The assessment of cholinesterase from the liver of Puntius javanicus as detection of metal ions.TheScientificWorldJournal · 2014Article
- Evaluation of epidemiology and animal data for risk assessment: chlorpyrifos developmental neurobehavioral outcomes.Journal of toxicology and environmental health. Part B, Critical reviews · 2012Review
- The protection of acetylcholinesterase inhibitor on β-amyloid-induced the injury of neurite outgrowth via regulating axon guidance related genes expression in neuronal cells.International journal of clinical and experimental pathology · 2012Article
- Role of acetylcholinesterase on the structure and function of cholinergic synapses: insights gained from studies on knockout mice.Cellular and molecular neurobiology · 2011Article
- Chlorpyrifos-oxon disrupts zebrafish axonal growth and motor behavior.Toxicological sciences : an official journal of the Society of Toxicology · 2011Article
- Revisiting the Role of Acetylcholinesterase in Alzheimer's Disease: Cross-Talk with P-tau and β-Amyloid.Frontiers in molecular neuroscience · 2011Article
- Toxicogenomic profiling in maternal and fetal rodent brains following gestational exposure to chlorpyrifos.Toxicology and applied pharmacology · 2010Article
- Developmental chlorpyrifos and methyl parathion exposure alters radial-arm maze performance in juvenile and adult rats.Toxicological sciences : an official journal of the Society of Toxicology · 2009Article
- Effect of different administration paradigms on cholinesterase inhibition following repeated chlorpyrifos exposure in late preweanling rats.Toxicological sciences : an official journal of the Society of Toxicology · 2008Article
- Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase.Toxicology and applied pharmacology · 2008Article
- In utero methanesulfonyl fluoride differentially affects learning and maze performance in the absence of long-lasting cholinergic changes in the adult rat.Pharmacology, biochemistry, and behavior · 2008Article
- Exposure to organophosphates reduces the expression of neurotrophic factors in neonatal rat brain regions: similarities and differences in the effects of chlorpyrifos and diazinon on the fibroblast growth factor superfamily.Environmental health perspectives · 2007Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developing animals are more sensitive than adults to acute cholinergic toxicity from anticholinesterases, including organophosphorus pesticides, when administered in a laboratory setting. It is also possible that these agents adversely affect the process of neural development itself, leading to permanent deficits in the architecture of the central and peripheral nervous systems. Recent observations indicate that organophosphorus exposure can affect DNA synthesis and cell survival in neonatal rat brain. New evidence that acetylcholinesterase may have a direct role in neuronal differentiation provides additional grounds for interest in the developmental toxicity of anticholinesterases. For example, correlative anatomic studies show that transient bursts of acetylcholinesterase expression often coincide with periods of axonal outgrowth in maturing avian, rodent, and primate brain. Some selective cholinesterase inhibitors effectively suppress neurite outgrowth in model systems like differentiating neuroblastoma cells and explanted sensory ganglia. When enzyme expression is altered by genetic engineering, acetylcholinesterase levels on the outer surface of transfected neurons correlate with ability to extend neurites. Certain of these "morphogenic" effects may depend on protein-protein interactions rather than catalytic acetylcholinesterase activity. Nonetheless, it remains possible that some pesticides interfere with important developmental functions of the cholinesterase enzyme family.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.